Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats
Aksu B, Ayvaz S, Aksu F, Karaca T, Cemek M, Ayaz A, Demirtaş S. Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats. Journal Of Pediatric Surgery 2014, 50: 591-597. PMID: 25840069, DOI: 10.1016/j.jpedsurg.2014.06.007.Peer-Reviewed Original ResearchConceptsAcute lung injuryPulmonary contusionLung injuryInducible nitric oxide synthaseLung tissueSeverity of lung injurySphingosylphosphorylcholine treatmentAdministered 3 daysNitric oxideAttenuated lung damageOxidative stressNitric oxide synthaseEffects of sphingosylphosphorylcholineGlutathione peroxidaseDepletion of superoxide dismutaseSuperoxide dismutaseLung malondialdehydeHistopathological findingsPositive cellsLung damageImmunohistochemical changesInflammatory processNeutrophil activationOxide synthaseApoptotic cells