About
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Associate Research Scientist
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Associate Research ScientistPrimary
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Research
Research at a Glance
Publications Timeline
A big-picture view of Ahmet Ayaz's research output by year.
33Publications
506Citations
Publications
2019
The Impact of Single and Multiple Sperm Abnormalities and Low-Level Leukocytospermia on Sperm DNA
Alshahrani S, Ahmad G, Khan H, Ayaz A, Ali A. The Impact of Single and Multiple Sperm Abnormalities and Low-Level Leukocytospermia on Sperm DNA. Journal Of Men's Health 2019, 15: e51-e58. DOI: 10.22374/jomh.v15i2.144.Peer-Reviewed Original ResearchCitationsConceptsStandard sperm parametersSperm parametersDNA damageAnalysis of semen characteristicsCohort of infertile menSperm DNA testingSperm DNA damageDNA fragmentation analysisLevel of leukocytospermiaNick end labelingSperm motilityInfertile menSemen characteristicsSpermSperm abnormalitiesSperm DNASemen abnormalitiesPercentage of DNA damageRetrospective analysisFragment analysisDNAAbnormal parametersART treatmentEnd labelingDNA testing
2018
Proteomic analysis of sperm proteins in infertile men with high levels of reactive oxygen species
Ayaz A, Agarwal A, Sharma R, Kothandaraman N, Cakar Z, Sikka S. Proteomic analysis of sperm proteins in infertile men with high levels of reactive oxygen species. Andrologia 2018, 50: e13015. PMID: 29656391, DOI: 10.1111/and.13015.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAmyloid beta-Protein PrecursorAntigens, NeoplasmF-Box ProteinsHSP70 Heat-Shock ProteinsHumansInfertility, MaleMaleMAP Kinase Kinase Kinase 3Nerve Tissue ProteinsNitric Oxide Synthase Type IIPeptidyl-Dipeptidase AProteomicsReactive Oxygen SpeciesRibosomal ProteinsSmall Ubiquitin-Related Modifier ProteinsSpermatozoaTestisUbiquitinsConceptsReactive oxygen speciesSperm proteinsMale infertilityAngiotensin-converting enzymePost-acrosomal regionPoor sperm qualityLevels of reactive oxygen speciesSperm qualityTesticular environmentInfertile menHeat shock proteinsProteomic analysisHSPA2SpermatozoaExpression profilesOxidative stressRPS27aProteinOxygen speciesMAP3K3Western blottingNeck areaRisk factorsUBL4ASpermChapter 23 Standardized Semen Analysis and Quality Control Management for Multicenter Male Reproductive Toxicology Clinical Trials
Sikka S, Ayaz A. Chapter 23 Standardized Semen Analysis and Quality Control Management for Multicenter Male Reproductive Toxicology Clinical Trials. 2018, 371-386. DOI: 10.1016/b978-0-12-801299-4.00023-2.Peer-Reviewed Original ResearchCitationsConceptsSemen analysisReproductive failureVariable predictive valueIncidence of reproductive failureHormonal evaluationMen's reproductive healthExposure to endocrine-disrupting chemicalsSemen samplesClinical trialsIncreased incidencePredictive valueLaboratory evaluationReproductive healthTobacco smokeFood additivesNonstandardized techniqueReproductive endocrinologyToxicity trialsSemenStress factorsControl managementEndocrine-disrupting chemicalsLack of standardizationGenetic issuesCounting chamberChapter 21 Impact of Environmental Factors on the Genomics and Proteomics Landscapes of Male Infertility
Ayaz A, Kothandaraman N, Henkel R, Sikka S. Chapter 21 Impact of Environmental Factors on the Genomics and Proteomics Landscapes of Male Infertility. 2018, 335-353. DOI: 10.1016/b978-0-12-801299-4.00021-9.Peer-Reviewed Original ResearchCitationsConceptsGenetic materialMale infertilityAnalysis of posttranslational modificationsSperm genetic materialSperm epigenomeFunctional genomicsPosttranslational modificationsEnvironmental factorsMicroarray technologyProteomic landscapeGlobal proteinGenetic changesReproductive cellsCritical proteinsDNA structureBioinformatics applicationsProteomic techniquesAdverse effects of environmentGenomeProteinProteomicsDNAImpact of environmental factorsHigh-resolution assessmentInfertile couples
2017
Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review
Darbandi S, Darbandi M, Khorram Khorshid H, Shirazi A, Sadeghi M, Agarwal A, Al-Hasani S, Naderi M, Ayaz A, i Akhondi M. Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review. International Journal Of Reproductive BioMedicine (IJRM) 2017, 15: 601-612. DOI: 10.29252/ijrm.15.10.1.Peer-Reviewed Original ResearchCitationsReconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review
Darbandi S, Darbandi M, Khorram Khorshid H, Shirazi A, Sadeghi M, Agarwal A, Al-Hasani S, Naderi M, Ayaz A, Akhondi M. Reconstruction of mammalian oocytes by germinal vesicle transfer: A systematic review. International Journal Of Reproductive BioMedicine (IJRM) 2017, 15: 601-612. PMID: 29387825, PMCID: PMC5767640, DOI: 10.29252/ijrm.15.10.2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsGerminal vesicle stage oocytesGerminal vesicle transferNuclear transfer proceduresAssisted reproductive techniquesMitochondrial problemsVesicle transferNuclear transfer techniqueMammalian speciesPotential clinical applicationsOocyte activationMammalian oocytesReproductive techniquesStage oocytesSurvival rateEffective treatmentOocytesOlder oocytesClinical applicationTransfer proceduresTransfer techniqueSpeciesDifferential expression and localization of ACE and MAP3K3 in oxidative stress related male infertility
Ayaz A, Kothandaraman N, Agarwal A, Cakar Z, Sikka S, Sabanegh E, Sharma R. Differential expression and localization of ACE and MAP3K3 in oxidative stress related male infertility. Fertility And Sterility 2017, 108: e317-e318. DOI: 10.1016/j.fertnstert.2017.07.941.Peer-Reviewed Original ResearchMulti-center evaluation of oxidation reduction potential assay in the infertile male
Agarwal A, Chandrakumar R, Arafa M, Elbardisi H, Okada H, Suzuki K, Homa S, Killeen A, Balaban B, Ayaz A, Saleh R, Armagan A, Roychoudhury S, Sikka S. Multi-center evaluation of oxidation reduction potential assay in the infertile male. Fertility And Sterility 2017, 108: e317. DOI: 10.1016/j.fertnstert.2017.07.939.Peer-Reviewed Original ResearchCitations
2016
Infertile men have a redox imbalance that distinguishes them from fertile men
Ayaz A, Bjugstad K, Bar-Or D, Armagan A. Infertile men have a redox imbalance that distinguishes them from fertile men. Fertility And Sterility 2016, 106: e235. DOI: 10.1016/j.fertnstert.2016.07.678.Peer-Reviewed Original ResearchCitationsAltmetricPost-Translational Modifications in sperm Proteome: The Chemistry of Proteome diversifications in the Pathophysiology of male factor infertility
Samanta L, Swain N, Ayaz A, Venugopal V, Agarwal A. Post-Translational Modifications in sperm Proteome: The Chemistry of Proteome diversifications in the Pathophysiology of male factor infertility. Biochimica Et Biophysica Acta 2016, 1860: 1450-1465. PMID: 27062907, DOI: 10.1016/j.bbagen.2016.04.001.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPost-translational modificationsSperm proteinsSperm functionOccurrence of post-translational modificationsExpressed protein complementHuman sperm proteinsProtein synthesis machineryAnalysis of post-translational modificationsComplex interaction networksProteome diversificationSperm proteomeFemale reproductive tractHuman spermatozoaProtein complementStructure-function relationshipsSynthesis machineryInteraction networkProtein stabilityMale infertilitySpermMale factor infertilitySpermatozoaProtein profilesDifferential occurrenceFertility potential
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