PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease
Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease. PLOS Genetics 2021, 17: e1009406. PMID: 33830999, PMCID: PMC8031396, DOI: 10.1371/journal.pgen.1009406.Peer-Reviewed Original ResearchConceptsΒ-amyloid plaquesAlzheimer's diseaseCerebral β-amyloidosisΒ-amyloid pathologyPhospholipase D3Sporadic Alzheimer's diseaseNormal human brainPre-frontal cortexAD-affected brainsFear conditioning taskReligious Orders StudyΒ-amyloidosisAD brainMouse modelAD riskCognitive declineMouse brainPhospholipase D isoformsCognitive functionPathology severityMouse strainsDiseaseBrainRush MemoryMRNA levels