2021
PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease
Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease. PLOS Genetics 2021, 17: e1009406. PMID: 33830999, PMCID: PMC8031396, DOI: 10.1371/journal.pgen.1009406.Peer-Reviewed Original ResearchConceptsΒ-amyloid plaquesAlzheimer's diseaseCerebral β-amyloidosisΒ-amyloid pathologyPhospholipase D3Sporadic Alzheimer's diseaseNormal human brainPre-frontal cortexAD-affected brainsFear conditioning taskReligious Orders StudyΒ-amyloidosisAD brainMouse modelAD riskCognitive declineMouse brainPhospholipase D isoformsCognitive functionPathology severityMouse strainsDiseaseBrainRush MemoryMRNA levels
2020
PLD3 is a neuronal lysosomal phospholipase D associated with β‐amyloid plaques and cognitive function in Alzheimer’s disease
Nackenoff A, Hohman T, Neuner S, Akers C, Weitzel N, Shostak A, Ferguson S, Bennett D, Schneider J, Jefferson A, Kaczorowski C, Schrag M. PLD3 is a neuronal lysosomal phospholipase D associated with β‐amyloid plaques and cognitive function in Alzheimer’s disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043301.Peer-Reviewed Original ResearchSporadic Alzheimer's diseaseΒ-amyloid plaquesAlzheimer's diseaseCerebral β-amyloidosisΒ-amyloid pathologyPhospholipase D3Normal human brainPre-frontal cortexAD-affected brainsFear conditioning taskReligious Orders StudyDystrophic neuritesAD brainΒ-amyloidosisMouse modelCognitive declineMouse brainPhospholipase D isoformsCognitive functionPathology severityMouse strainsDiseaseBrainRush MemoryMRNA levels
2018
A Novel Murine Knock‐in Model for Progranulin‐deficient Frontotemporal Dementia with Nonsense‐mediated mRNA Decay
Nguyen A, Nguyen T, Zhang J, Devireddy S, Zhou P, Karydas A, Xu X, Miller B, Rigo F, Ferguson S, Huang E, Walther T, Farese R. A Novel Murine Knock‐in Model for Progranulin‐deficient Frontotemporal Dementia with Nonsense‐mediated mRNA Decay. The FASEB Journal 2018, 32: 807.8-807.8. DOI: 10.1096/fasebj.2018.32.1_supplement.807.8.Peer-Reviewed Original ResearchFrontotemporal dementiaMRNA levelsProgranulin-deficient frontotemporal dementiaCommon neurodegenerative disorderExcessive grooming behaviorGrn knockout miceCell linesFull-text articlesSynaptic densityProgranulin deficiencyTesting therapiesGRN mutationsTherapeutic approachesKnockout miceAnimal modelsAge 60GRN mRNA levelsNeurodegenerative disordersNonsense mutationMiceProgranulin proteinText articlesNational InstituteTypes of mutationsDementia research