2013
Region‐specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome
Hayrapetyan V, Castro S, Sukharnikova T, Yu C, Cao X, Jiang YH, Yin HH. Region‐specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome. European Journal Of Neuroscience 2013, 39: 1018-1025. PMID: 24329862, PMCID: PMC5937017, DOI: 10.1111/ejn.12442.Peer-Reviewed Original ResearchConceptsDorsolateral striatumDorsomedial striatumMouse modelAngelman syndromeWhole-cell patch-clamp recordingsMiniature excitatory postsynaptic currentsRegion-specific impairmentsStriatal synaptic transmissionExcitatory postsynaptic currentsBasal ganglia pathologyPatch-clamp recordingsDeficient mouse modelUbe3a deficiencyWild-type controlsGlutamatergic transmissionPostsynaptic currentsBasal gangliaSynaptic transmissionInput nucleusMaternal deficiencyMotor tremorCorticostriatal circuitsMutant miceStriatumMice
2002
Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction
Smith CL, DeVera DG, Lamb DJ, Nawaz Z, Jiang YH, Beaudet AL, O’Malley B. Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction. Molecular And Cellular Biology 2002, 22: 525-535. PMID: 11756548, PMCID: PMC139730, DOI: 10.1128/mcb.22.2.525-535.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug ResistanceFemaleFertilityGene ExpressionGrowthHistone AcetyltransferasesLigasesMaleMammary Glands, AnimalMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Coactivator 1Nuclear Receptor Coactivator 3PregnancyProstateReceptors, SteroidReproductionSteroidsTrans-ActivatorsTranscription FactorsUbiquitin-Protein LigasesConceptsSteroid hormone actionWild-type controlsHormone actionProstate gland growthFemale knockout miceSteroid hormone resistanceE6-APSex steroid actionSteroid receptor coactivatorVirgin mammary glandMammary gland developmentReceptor-dependent gene expressionFemale miceUterine growthHormone resistanceSteroid actionKnockout miceNull miceGland growthType 1Genetic ablationMammary glandReceptor coactivatorMiceGland development