2022
PLD3 affects axonal spheroids and network defects in Alzheimer’s disease
Yuan P, Zhang M, Tong L, Morse T, McDougal R, Ding H, Chan D, Cai Y, Grutzendler J. PLD3 affects axonal spheroids and network defects in Alzheimer’s disease. Nature 2022, 612: 328-337. PMID: 36450991, PMCID: PMC9729106, DOI: 10.1038/s41586-022-05491-6.Peer-Reviewed Original ResearchConceptsAxonal spheroidsAlzheimer's diseaseConduction blockadeNeural circuit abnormalitiesNeural network dysfunctionAmyloid removalCircuit abnormalitiesAge-dependent accumulationNetwork dysfunctionEndolysosomal vesiclesMouse modelNeuronal overexpressionCognitive declineAxonal connectivityDiseasePrecise mechanismBlockadePLD3Neural network functionSpheroid growthSevere disruptionCurrent sinkVoltage imagingSize-dependent mannerDysfunction
2016
Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb
Short SM, Morse TM, McTavish TS, Shepherd GM, Verhagen JV. Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb. PLOS ONE 2016, 11: e0168356. PMID: 28005923, PMCID: PMC5179112, DOI: 10.1371/journal.pone.0168356.Peer-Reviewed Original ResearchConceptsMitral cell layerOlfactory bulbCell layerPeriod of inhalationOdor processingGranule cell layerGranule cell inhibitionSingle-unit recordingsMitral/Inhibitory responsesUnit recordingsAction potentialsMTC responsesRespiratory cycleCell inhibitionSensory processingDiscrete sensory inputsInhibitory mechanismSensory responsesSensory inputInhalationMechanism of inhibitionInhibitory activityInhibitionSensory
2013
Compartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic