2013
Compartmentalization of GABAergic Inhibition by Dendritic Spines
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic Inhibition by Dendritic Spines. Science 2013, 340: 759-762. PMID: 23661763, PMCID: PMC3752161, DOI: 10.1126/science.1234274.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionDendritic spinesPerisomatic inhibitory synapsesPyramidal cell dendritesTwo-photon calcium imagingAction potential outputAcid-mediated inhibitionIndividual dendritic spinesGABAergic controlGABAergic synapsesPyramidal neuronsCell dendritesInhibitory synapsesNeuronal activityCalcium imagingSpine headsInhibitory actionNeocortexInhibitionSpineSynapsesCompartmentalized controlCritical roleSignalingPostsynaptic
2010
Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study
Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM. Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Frontiers In Neural Circuits 2010, 4: 16. PMID: 20725509, PMCID: PMC2901152, DOI: 10.3389/fncir.2010.00016.Peer-Reviewed Original ResearchOblique dendritesCognitive functionEarly Alzheimer'sPyramidal cell dendritesAmyloid beta proteinNeural basisAbnormal excitabilityPyramidal dendritesProximal dendritesDistal dendritesCell dendritesApical trunkAnimal modelsElectrophysiological studiesAction potentialsOblique branchHyperexcitabilityExcessive calcium concentrationsCalcium concentrationEarly exposureIntegrative propertiesBeta proteinEarly declineRecording sitesAlzheimer's