2017
Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS
Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, Funakoshi K, Kawahara N, Goshima Y, Strittmatter SM, Takei K. Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS. Scientific Reports 2017, 7: 12119. PMID: 28935984, PMCID: PMC5608707, DOI: 10.1038/s41598-017-12449-6.Peer-Reviewed Original ResearchConceptsSpinal cord injuryOptic nerve crushAxonal regenerationMotor recoveryNerve crushNeural repairRetinal ganglion cell axonal regenerationAdult mammalian central nervous systemIntrinsic motor recoverySpontaneous neural repairAxonal growth inhibitorsMammalian central nervous systemCentral nervous systemNon-permissive environmentLevel of functionUntreated miceFunctional recoveryCord injuryReceptor antagonistNeuronal overexpressionNervous systemGenetic deletionViral overexpressionCrushInhibitors
2011
Cartilage Acidic Protein–1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation
Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K. Cartilage Acidic Protein–1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation. Science 2011, 333: 769-773. PMID: 21817055, PMCID: PMC3244695, DOI: 10.1126/science.1204144.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBinding SitesCalcium-Binding ProteinsCell LineCells, CulturedGPI-Linked ProteinsGrowth ConesHumansImmunohistochemistryLigandsMiceMice, Inbred ICRMyelin ProteinsNogo ProteinsNogo Receptor 1Olfactory PathwaysProsencephalonProtein BindingReceptors, Cell SurfaceSignal TransductionConceptsTract formationNogo receptor 1Axon growth inhibitorsProtein 1BEndogenous antagonismAxon tract formationReceptor antagonistGrowth cone collapseAxonal projectionsCircuitry formationNeural circuitry formationMouse brainReceptor 1LOT formationNeural regenerationNgR1Key moleculesCone collapseMiceFluorophore-assisted light inactivationGrowth inhibitorAntagonistBrainMyelinNogoInosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke
Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM, Benowitz LI. Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke. Journal Of Neuroscience 2011, 31: 5977-5988. PMID: 21508223, PMCID: PMC3101108, DOI: 10.1523/jneurosci.4498-10.2011.Peer-Reviewed Original ResearchConceptsIntrinsic growth potentialUnilateral strokeSpinal cordLayer 5 pyramidal neuronsForelimb motor areaSimilar functional improvementEnvironmental enrichmentCause of disabilitySkilled forelimb useEffect of treatmentUndamaged cortexReceptor blockersDenervated sidePreoperative levelsNEP1-40Stroke patientsPyramidal neuronsUndamaged hemisphereSkilled reachingTreatment optionsDenervated areaIntact hemisphereReceptor antagonistClinical trialsFunctional improvement
2003
Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury
Li S, Strittmatter SM. Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury. Journal Of Neuroscience 2003, 23: 4219-4227. PMID: 12764110, PMCID: PMC6741116, DOI: 10.1523/jneurosci.23-10-04219.2003.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsAxotomyBehavior, AnimalCornified Envelope Proline-Rich ProteinsFemaleGanglia, SpinalGPI-Linked ProteinsInjections, SubcutaneousIntralaminar Thalamic NucleiMembrane ProteinsMiceMice, Inbred C57BLMolecular Sequence DataMolecular WeightMotor ActivityMyelin ProteinsNerve FibersNerve RegenerationNogo Receptor 1Peptide FragmentsProtein BiosynthesisProteinsPyramidal TractsReceptors, Cell SurfaceSerotoninSpinal CordSpinal Cord InjuriesConceptsSpinal cord injuryCord injuryCorticospinal axonsThoracic spinal cord injuryTherapeutic time windowSpinal cord hemisectionSpinal cord traumaCorticospinal tract axonsAdult mammalian CNSNogo-66 receptorOligodendrocyte myelin glycoproteinCNS axonal injuryCord lesionsSubcutaneous treatmentSystemic therapyCord hemisectionCord traumaIntrathecal applicationLocal therapyLocomotor recoveryFunctional recoverySerotonergic fibersAxonal injuryReceptor antagonistAxon sprouting