2011
Reduced locomotor responses to cocaine in ghrelin-deficient mice
Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL. Reduced locomotor responses to cocaine in ghrelin-deficient mice. Neuroscience 2011, 192: 500-506. PMID: 21699961, DOI: 10.1016/j.neuroscience.2011.06.001.Peer-Reviewed Original ResearchConceptsGhrelin KO miceWT miceDopamine releaseLocomotor activityBehavioral effectsDopamine metabolite concentrationsGhrelin-deficient miceLocomotor-stimulating effectsDopamine cell activityEffects of cocaineMesolimbic dopaminergic systemWild-type littermatesOrexigenic hormoneChronic injectionsDopamine utilizationDaily injectionsStriatal dopamineMesolimbic systemWT littermatesDopaminergic systemDaily cocaineFood intakeRewarding effectsPsychostimulant effectsLocomotor response
2004
Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
Wehner JM, Keller JJ, Keller AB, Picciotto MR, Paylor R, Booker TK, Beaudet A, Heinemann SF, Balogh SA. Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience 2004, 129: 11-24. PMID: 15489024, DOI: 10.1016/j.neuroscience.2004.07.016.Peer-Reviewed Original ResearchConceptsContextual learningForms of learningEffects of nicotineFear conditioningCued fear conditioningContextual fear conditioningCognitive enhancing effectsBeta2 null mutant miceNicotine effectsBeta4-containing receptorsShock stimuliEffects of ethanolBeta2-containing nAChRsLearningNull mutant miceTrainingConditioningBrain nicotinic acetylcholine receptorsMutant miceNicotineNeuronal nicotinic receptorsHomozygous null mutant miceWild-type littermatesMemoryNicotinic acetylcholine receptors