2024
Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs
Wang T, Ling A, Billings S, Hosseini D, Vaisbuch Y, Kim G, Atkinson P, Sayyid Z, Aaron K, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore L, Maria P, Blevins N, Jackler R, Alyono J, Kveton J, Navaratnam D, Heller S, Lopez I, Grillet N, Jan T, Cheng A. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nature Communications 2024, 15: 4833. PMID: 38844821, PMCID: PMC11156867, DOI: 10.1038/s41467-024-48491-y.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptome atlasInner ear hair cell lossNon-sensory cell typesCell regeneration in vivoVestibular schwannoma patientsTranscriptomic atlasHair cellsHair cell lossIGF-1 signalingHuman inner earMouse hair cellsCell trajectory analysisSchwannoma patientsDynamic gene expressionVestibular hair cellsPermanent hearingHair cell precursorsIGF-1Cell lossCell precursorsInner earRegenerative capacityMurine utriclesCell typesGene expressionReply to "Considering Health Systems Worldwide: Point of View From a Middle-Income Country".
Tu L, Melnick E, Venkatesh A, Sheth K, Navaratnam D, Yaesoubi R, Forman H, Mahajan A. Reply to "Considering Health Systems Worldwide: Point of View From a Middle-Income Country". American Journal Of Roentgenology 2024, 222: e2430900. PMID: 38294162, DOI: 10.2214/ajr.24.30900.Peer-Reviewed Original Research
2023
Cost-Effectiveness of CT, CTA, MRI, and Specialized MRI for Evaluation of Patients Presenting to the Emergency Department With Dizziness.
Tu L, Melnick E, Venkatesh A, Sheth K, Navaratnam D, Yaesoubi R, Forman H, Mahajan A. Cost-Effectiveness of CT, CTA, MRI, and Specialized MRI for Evaluation of Patients Presenting to the Emergency Department With Dizziness. American Journal Of Roentgenology 2023, 222: e2330060. PMID: 37937837, DOI: 10.2214/ajr.23.30060.Peer-Reviewed Original ResearchQuality-adjusted life yearsEvaluation of patientsSecondary prevention measuresEmergency departmentProbabilistic sensitivity analysesConventional MRICumulative quality-adjusted life yearsCost-effective strategyIncremental costNoncontrast CT headAcute stroke treatmentSpecialized MRISelection of patientsHigher quality-adjusted life yearsConventional brain MRIMarkov decision-analytic modelNon-contrast CTNoncontrast head CTHealthcare system perspectiveUse of MRIBase-case analysisPrevention measuresDecision analytic modelGreater quality-adjusted life yearsDeterministic sensitivity analysesCT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsClinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness
Tu L, Malhotra A, Venkatesh A, Taylor R, Sheth K, Yaesoubi R, Forman H, Sureshanand S, Navaratnam D. Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLOS ONE 2023, 18: e0280752. PMID: 36893103, PMCID: PMC9997874, DOI: 10.1371/journal.pone.0280752.Peer-Reviewed Original ResearchConceptsAcute vascular pathologyEmergency departmentVascular pathologyNegative predictive valueDizzy patientsStroke codeCTA headPredictive valueAdult ED encountersTransient ischemic attackHalf of patientsLong-term smokersLarge vessel occlusionCoronary artery diseasePast medical historySeparate validation cohortCross-sectional analysisIschemic attackAnalysis cohortArterial dissectionArtery diseaseClinical factorsED encountersMedication useChief complaintMegahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
Santos-Sacchi J, Bai J, Navaratnam D. Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification. Journal Of Neuroscience 2023, 43: 2460-2468. PMID: 36868859, PMCID: PMC10082455, DOI: 10.1523/jneurosci.2033-22.2023.Peer-Reviewed Original ResearchConceptsConformational switchingMammalian hearingMembrane motor proteinCochlear amplificationMotor protein prestinVoltage-sensor charge movementOuter hair cell electromotilityHair cell electromotilityProtein prestinMotor proteinsConformation switchingCharge movementPrestinPrestin activityCell membraneOHC electromotilityHair cell membraneElectromotilityTransmembrane voltageOrgan of CortiAmplificationMammalsMembrane capacitanceProtein
2021
Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402)
McAlpine L, Zubair A, Maran I, Chojecka P, Lleva P, Jasne A, Navaratnam D, Matouk C, Schindler J, Chun H, Lee A, Spudich S, Sharma R, Sansing L. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2402.Peer-Reviewed Original Research
2019
Cytomegalovirus infects the developing Organ of Corti in a mouse model of virally induced deafness
Ornaghi S, Bai J, Santos-Sacchi J, Navaratnam D, Vergani P, van den Pol A, Paidas M. Cytomegalovirus infects the developing Organ of Corti in a mouse model of virally induced deafness. American Journal Of Obstetrics And Gynecology 2019, 221: 695-696. DOI: 10.1016/j.ajog.2019.10.063.Peer-Reviewed Original ResearchThrombotic thrombocytopenic purpura (TTP) presenting with severe neurological manifestations in a patient with well-controlled HIV-1 (P4.9-010)
Kimbrough T, Sanmartin P, Litvinov B, Navaratnam D. Thrombotic thrombocytopenic purpura (TTP) presenting with severe neurological manifestations in a patient with well-controlled HIV-1 (P4.9-010). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p4.9-010.Peer-Reviewed Original ResearchVestibular Migraine
Schettino A, Navaratnam D. Vestibular Migraine. 2019, 255-276. DOI: 10.1007/978-3-319-97858-1_18.Peer-Reviewed Original ResearchCauses of Central Vertigo
Lawal O, Navaratnam D. Causes of Central Vertigo. 2019, 363-375. DOI: 10.1007/978-3-319-97858-1_25.Peer-Reviewed Original Research
2018
5: Valnoctamide rescues CMV-induced deafness in a murine model
Ornaghi S, Bai J, Navaratnam D, Santos-Sacchi J, Vergani P, van den Pol A, Paidas M. 5: Valnoctamide rescues CMV-induced deafness in a murine model. American Journal Of Obstetrics And Gynecology 2018, 218: s4-s5. DOI: 10.1016/j.ajog.2017.10.416.Peer-Reviewed Original Research
2017
Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility
Santos-Sacchi J, Navaratnam D, Raphael R, Oliver D. Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility. Springer Handbook Of Auditory Research 2017, 62: 113-145. DOI: 10.1007/978-3-319-52073-5_5.Peer-Reviewed Original ResearchOuter hair cellsMammalian inner earOuter Hair Cell ElectromotilityHair cell electromotilitySLC26 familyMolecular mechanismsMembrane lipidsConformational changesMechanical feedback mechanismMolecular motorsTension sensitivityPrestinHair cellsVoltage-sensor charge movementAnion transportersReceptor potentialProteinMolecular conformational changesInner earStructural determinationIntracellular chlorideCharge movementTraffickingFeedback mechanismMechanism
2015
An Un-Bleachable YFP-Based Chloride Sensor
Zhong S, Navaratnam D, Santos-Sacchi J. An Un-Bleachable YFP-Based Chloride Sensor. Biophysical Journal 2015, 108: 312a. DOI: 10.1016/j.bpj.2014.11.1695.Peer-Reviewed Original Research
2013
Removing pH-Sensitivity and Improving Photostability of a Genetically-Encoded Chloride Sensor
Zhong S, Navaratnam D, Santos-Sacchi J. Removing pH-Sensitivity and Improving Photostability of a Genetically-Encoded Chloride Sensor. Biophysical Journal 2013, 104: 348a-349a. DOI: 10.1016/j.bpj.2012.11.1935.Peer-Reviewed Original Research
2012
Chloride Flux in Prestin-Expressing Cells
Zhong S, Bian S, Navaratnam D, Santos-Sacchi J. Chloride Flux in Prestin-Expressing Cells. Biophysical Journal 2012, 102: 246a. DOI: 10.1016/j.bpj.2011.11.1355.Peer-Reviewed Original Research
2011
Evaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell Line
Bian S, Koo B, Kelleher S, Santos-Sacchi J, Navaratnam D, Shera C, Olson E. Evaluating Prestin's Changing Biophysical Attributes in Development Using a Tet‐Induced Cell Line. AIP Conference Proceedings 2011, 1403: 143-147. DOI: 10.1063/1.3658075.Peer-Reviewed Original Research
2008
Hair Cells–Beyond the Transducer
Housley G, Marcotti W, Navaratnam D, Yamoah E. Hair Cells–Beyond the Transducer. The Journal Of Membrane Biology 2008, 223: 173-173. DOI: 10.1007/s00232-008-9109-5.Peer-Reviewed Original Research
2007
Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.Peer-Reviewed Original ResearchConceptsLateral membranesOuter hair cellsMouse outer hair cellsMotor protein activitySteady-state levelsKnockout experimentsProtein activityDevelopmental expressionMembrane tensionGenetic modificationConformational fluctuationsCellular mechanismsMotor moleculesMolecular motorsOnset of hearingMorphological estimatesProtein densityEarly maturationQuantitative polymerase chain reactionHair cellsVpkCmDevelopmental dataCochlear amplificationMaturationFull maturation
2006
CHLORIDE AND THE OHC LATERAL MEMBRANE MOTOR
SANTOS-SACCHI J, SONG L, BAI J, NAVARATNAM D. CHLORIDE AND THE OHC LATERAL MEMBRANE MOTOR. 2006, 162-168. DOI: 10.1142/9789812773456_0028.Peer-Reviewed Original Research