2024
Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz M. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. The EMBO Journal 2024, 43: 3175-3191. PMID: 38886581, PMCID: PMC11294477, DOI: 10.1038/s44318-024-00142-0.Peer-Reviewed Original ResearchLatrophilin-2Affinity purification methodCell-cell junctionsHuman genetic dataPECAM-1SiRNA screenGenetic dataEndothelial cell response to fluid shear stressGA proteinsDownstream eventsEndothelial-specific knockoutG-proteinActivity assayShear stress mechanotransductionPlexin-D1Endothelial signalingJunctional complexesPurification methodVE-cadherinResponse to fluid shear stressVascular developmentGA residuesEndothelial junctionsGPCRsVEGF receptorsImpact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice
Yao X, Chen R, Chen H, Koleske A, Xiao X. Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice. Behavioural Brain Research 2024, 468: 115022. PMID: 38697301, DOI: 10.1016/j.bbr.2024.115022.Peer-Reviewed Original ResearchDepressive-like behaviorBehavioral testsMarble-burying behavior testAnxiety/depression-related behaviorsAnxiety-like behaviorElevated plus mazeTail suspension testEmotion-related behaviorsOpen field testWT micePlus mazeDepressive behaviorSuspension testAgonist gaboxadolMemory deficitsY-mazeAnxietyInhibitory neurotransmissionCompared to WT miceSensory/motor functionTissue injury responsesWild-typeHippocampusGABAergic synapseIntraperitoneal treatment
2023
Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression
Malnassy G, Keating C, Gad S, Bridgeman B, Perera A, Hou W, Cotler S, Ding X, Choudhry M, Sun Z, Koleske A, Qiu W. Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 685-709. PMID: 37460041, PMCID: PMC10520367, DOI: 10.1016/j.jcmgh.2023.07.006.Peer-Reviewed Original ResearchConceptsAlcohol-fed miceLiver diseaseALD pathogenesisPPARγ expressionLiver injuryAlcohol feedingKnockout miceAlcohol-associated liver diseaseLiver tissueC57BL6/J miceAlcohol-induced accumulationAlcohol-induced steatosisOil Red O stainingWild-type miceHypoxia inducible factor 1 subunit alphaTreatment of ALDPPARγ protein expressionRed O stainingLiver-specific knockoutSubsequent lipid accumulationSubsequent RNA sequencingPotential molecular targetsAbl kinase inhibitorsQuantitative polymerase chain reactionLipid droplet formationCorrection: Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts
Bircher J, Koleske A. Correction: Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts. Journal Of Cell Science 2023, 136 PMID: 36763488, PMCID: PMC11034500, DOI: 10.1242/jcs.260984.Peer-Reviewed Original ResearchAbl2 mediates microtubule nucleation and repair via tubulin co-condensation
Duan D, Lyu W, Wu K, Wu C, Xiong Y, Koleske A. Abl2 mediates microtubule nucleation and repair via tubulin co-condensation. Biophysical Journal 2023, 122: 124a. DOI: 10.1016/j.bpj.2022.11.839.Peer-Reviewed Original Research
2021
Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
Lukic N, Saha T, Lapetina S, Gendler M, Lehmann G, Koleske A, Gil-Henn H. Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy. Journal Of Visualized Experiments 2021 DOI: 10.3791/63157-v.Peer-Reviewed Original ResearchWhat is the role of synaptic protein TRIO's spectrin repeats?
Corcoran E, Bircher J, Koleske A. What is the role of synaptic protein TRIO's spectrin repeats? The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.01837.Peer-Reviewed Original ResearchSpectrin repeatsProper neuronal developmentSpectrin repeat domainRare damaging variantsDisease-associated mutationsAccessory domainsCatalytic domainRepeat domainRegulatory proteinsRepeat functionDe novo missense mutationsSignaling mechanismDamaging mutationsNeuronal developmentDamaging variantsDisease mutationsBiochemical eventsNovo missense mutationNeurodevelopmental disordersMissense mutationsSpectrinRepeatsMutationsDomainTherapeutic strategies
2018
Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase
Wang Z, Kim MS, Martinez-Ferrando I, Koleske A, Pandey A, Cole P. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry 2018, 57: 1390-1398. PMID: 29341593, PMCID: PMC5906802, DOI: 10.1021/acs.biochem.7b01158.Peer-Reviewed Original ResearchConceptsProtein kinaseNonreceptor tyrosine kinases AblMass spectrometry-based quantitative proteomicsNovel putative substratesTyrosine kinase AblCellular tyrosine phosphorylationExtracellular growth factorsChemical rescue approachIntracellular signal transductionQuantitative phosphoproteomicsUnanticipated functionCellular physiologyGrowth factorPhosphorylation sitesPutative substratesDirect substrateDownstream substratesSignal transductionReceptor kinaseQuantitative proteomicsTyrosine phosphorylationActive Abl kinasesAbl kinaseChemical rescueKinase
2017
Long‐Term Live‐Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI‐SiR
Thompson A, Omar M, Rivera‐Molina F, Xi Z, Koleske A, Toomre D, Schepartz A. Long‐Term Live‐Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI‐SiR. Angewandte Chemie 2017, 129: 10544-10548. DOI: 10.1002/ange.201704783.Peer-Reviewed Original Research
2016
Dendrite Maintenance
Katrancha S, Koleske A. Dendrite Maintenance. 2016, 317-355. DOI: 10.1007/978-4-431-56050-0_14.Peer-Reviewed Original ResearchDendritic spinesArbor stabilityDendrite arborsCytoplasmic nonreceptor tyrosine kinaseDendritic spine formationDendritic spine stabilityProper brain functionPsychiatric illnessSpine stabilityDifferent pathological statesSynaptic connectionsSpine formationBrain functionNormal agingNeurodegenerative diseasesMajor contributing factorSpinePathological statesReceptorsArborsEph receptorsContributing factorTyrosine kinaseCell surface adhesion receptorsMolecular mechanisms
2013
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
Um J, Kaufman A, Kostylev M, Heiss J, Stagi M, Takahashi H, Kerrisk M, Vortmeyer A, Wisniewski T, Koleske A, Gunther E, Nygaard H, Strittmatter S. Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein. Neuron 2013, 80: 531. DOI: 10.1016/j.neuron.2013.10.001.Peer-Reviewed Original Researchc-ABL Gene and Gene Product
Rosenberg B, Koleske A. c-ABL Gene and Gene Product. 2013, 401-403. DOI: 10.1016/b978-0-12-374984-0.00185-6.Peer-Reviewed Original Research
2012
Inside Cover: A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase (ChemBioChem 17/2012)
Deng Y, Couch B, Koleske A, Turk B. Inside Cover: A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase (ChemBioChem 17/2012). ChemBioChem 2012, 13: 2462-2462. DOI: 10.1002/cbic.201290071.Peer-Reviewed Original ResearchThe ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.
Cao C, Ren X, Kharbanda S, Koleske A, Prasad K, Kufe D. The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress. Journal Of Biological Chemistry 2012, 287: 36527. PMCID: PMC3476318, DOI: 10.1074/jbc.a112.100050.Peer-Reviewed Original Research
2011
Cell adhesion signaling pathways
Gourley S, Taylor J, Koleske A. Cell adhesion signaling pathways. Communicative & Integrative Biology 2011, 4: 30-33. DOI: 10.4161/cib.14083.Peer-Reviewed Original ResearchDendritic spinesDendritic spine structureChronic drug exposureCertain brain regionsExpression/functionDrug exposureCocaine exposurePsychomotor sensitizationPsychostimulant exposureBrain regionsNeuronal shapeSpine structureHuman brainExposureSpineTyrosine kinaseRecent findingsNonreceptor tyrosine kinaseCell adhesion receptorsAdhesion receptorsDevelopmental periodAdhesion factorsCell adhesion factorsFirst respondersCytoskeletal effectors
2007
Regulation of Neuronal Morphogenesis by Abl Family Kinases
Sultana H, Koleske A. Regulation of Neuronal Morphogenesis by Abl Family Kinases. 2007, 180-194. DOI: 10.1007/978-0-387-68561-8_8.Peer-Reviewed Original Research
2006
Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases
Koleske A. Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases. Molecular Biology Intelligence Unit 2006, 48-67. DOI: 10.1007/978-0-387-68744-5_5.Peer-Reviewed Original ResearchCell morphogenesisProtrusive structuresActin rich protrusive structuresFormation of actinAbl family kinasesNonreceptor tyrosine kinaseExtended C-terminusMetazoan organismsArp2/3 complexCytoskeletal dynamicsProtein complexesRac GTPasesExhibit defectsFamily kinasesNeuronal morphogenesisAbl familyCytoskeletal rearrangementsCytoskeletal networkCytoskeletal structuresEssential regulatorMutant animalsC-terminusActin filamentsTyrosine kinaseF-actin
2001
The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin
Wang Y, Miller A, Mooseker M, Koleske A. The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 14865-14870. PMID: 11752434, PMCID: PMC64950, DOI: 10.1073/pnas.251249298.Peer-Reviewed Original ResearchConceptsF-actin-binding domainActin-rich structuresAbl family kinasesNonreceptor tyrosine kinaseF-actinActin cytoskeletonFamily kinasesFluorescent protein fusion proteinTyrosine kinaseActin-bundling activityProtein fusion proteinActin cytoskeletal structuresCellular morphogenesisSwiss 3T3 fibroblastsBundling activityDeletion mutantsCytoskeletal structuresC-terminusFusion proteinFunctional interactionKinaseActin moleculesCytoskeletonPositive cooperativityArgThe ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress*
Cao C, Ren X, Kharbanda S, Koleske A, Prasad K, Kufe D. The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress*. Journal Of Biological Chemistry 2001, 276: 11465-11468. PMID: 11278261, DOI: 10.1074/jbc.c100050200.Peer-Reviewed Original Research
1998
Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation
Koleske A, Gifford A, Scott M, Nee M, Bronson R, Miczek K, Baltimore D. Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation. Neuron 1998, 21: 1259-1272. PMID: 9883720, DOI: 10.1016/s0896-6273(00)80646-7.Peer-Reviewed Original Research