James A. Giles, MD, PhD
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Assistant Professor
Biography
Dr. James Giles is a vascular neurologist at Yale School of Medicine. He completed medical school and a PhD in neuroscience in 2013 at The University of Manchester in the United Kingdom. He moved to the U.S. in 2014 to complete neurology residency, stroke fellowship and further stroke research training at Washington University School of Medicine. He also undertook a clinical research fellowship at Oxford University in 2020.
He moved to Yale in 2022, where he continues to take care of patients with cerebrovascular disease including ischemic and hemorrhagic stroke. His clinical and translational research has been funded by the National Institutes of Health and the American Heart Association.
Appointments
Neurology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Oxford University School of Medicine (2020)
- MPHS
- Washington University School of Medicine, Population Health Sciences (2020)
- Fellow
- Washington University School of Medicine (2019)
- Resident
- Washington University School of Medicine (2018)
- Chief Resident
- Washington University School of Medicine (2018)
- MD
- School of Medicine, The University of Manchester, Medicine (2013)
- PhD
- Faculty of Life Sciences, The University of Manchester, Neuroscience (2012)
Research
Overview
Medical Research Interests
Hemorrhagic Stroke; Ischemic Stroke
ORCID
0000-0002-3197-3062
Research at a Glance
Yale Co-Authors
Frequent collaborators of James A. Giles's published research.
Publications Timeline
A big-picture view of James A. Giles's research output by year.
Research Interests
Research topics James A. Giles is interested in exploring.
Elspeth Hill, MBChB, PhD, MRes, MRCS
Adam de Havenon, MD, MSCI
Adeel Zubair, MD
Alexandra Kimmel
Can Meng, MS, MPH
Fangyong Li, MS, MPH
28Publications
300Citations
Ischemic Stroke
Publications
2022
Predictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis
Shu L, Bakradze E, Omran SS, Giles J, Amar J, Henninger N, Elnazeir M, Liberman A, Moncrieffe K, Rotblat J, Sharma R, Cheng Y, Zubair AS, Simpkins A, Li G, Kung J, Perez D, Heldner MR, Scutelnic A, von Martial R, Siepen B, Rothstein A, Khazaal O, Do D, Al Kasab S, Rahman LA, Mistry EA, Kerrigan D, Lafever H, Nguyen TN, Klein P, Aparicio HJ, Frontera JA, Kuohn L, Agarwal S, Stretz C, Kala N, ElJamal S, Chang A, Cutting S, Indraswari F, de Havenon A, Muddasani V, Wu T, Wilson D, Nouh A, Asad D, Qureshi A, Moore J, Khatri P, Aziz Y, Casteigne B, Khan M, Cheng Y, Grory BM, Weiss M, Ryan D, Vedovati MC, Paciaroni M, Siegler J, Kamen S, Yu S, Guerrero CL, Atallah E, De Marchis GM, Brehm A, Dittrich T, Psychogios M, Alvarado-Dyer R, Kass-Hout T, Prabhakaran S, Honda T, Liebeskind D, Furie K, Yaghi S. Predictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis. Neurology 2022, 99: e2368-e2377. PMID: 36123126, PMCID: PMC9687409, DOI: 10.1212/wnl.0000000000201122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral venous thrombosisRecurrent venous thrombosisHistory of VTEVenous thrombosisVenous thromboembolismAntiphospholipid antibodiesBlack raceDiagnosis of CVTPositive antiphospholipid antibodiesRecurrent venous thrombosesAntiphospholipid antibody syndromeRecurrent venous thromboembolismCox regression analysisRisk of recurrenceMulticenter international studyAntibody syndromeOral anticoagulationVenous thrombosesConsecutive patientsRare causeMean ageTreatment strategiesThrombosisPatientsSecondary analysisDirect Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study
Yaghi S, Shu L, Bakradze E, Omran S, Giles JA, Amar JY, Henninger N, Elnazeir M, Liberman AL, Moncrieffe K, Lu J, Sharma R, Cheng Y, Zubair AS, Simpkins AN, Li GT, Kung JC, Perez D, Heldner M, Scutelnic A, Seiffge D, Siepen B, Rothstein A, Khazaal O, Do D, Al Kasab S, Rahman LA, Mistry EA, Kerrigan D, Lafever H, Nguyen TN, Klein P, Aparicio H, Frontera J, Kuohn L, Agarwal S, Stretz C, Kala N, Jamal S, Chang A, Cutting S, Xiao H, de Havenon A, Muddasani V, Wu T, Wilson D, Nouh A, Asad SD, Qureshi A, Moore J, Khatri P, Aziz Y, Casteigne B, Khan M, Cheng Y, Mac Grory B, Weiss M, Ryan D, Vedovati MC, Paciaroni M, Siegler JE, Kamen S, Yu S, Guerrero C, Atallah E, De Marchis GM, Brehm A, Dittrich T, Psychogios M, Alvarado-Dyer R, Kass-Hout T, Prabhakaran S, Honda T, Liebeskind DS, Furie K. Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study. Stroke 2022, 53: 728-738. PMID: 35143325, DOI: 10.1161/strokeaha.121.037541.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral venous thrombosisDirect oral anticoagulantsVenous thrombosisRecurrent venous thrombosisMajor hemorrhageInclusion criteriaDirect Oral Anticoagulants Versus WarfarinMulticenter international retrospective studyInverse probabilityInternational retrospective studySystemic venous thrombosisFavorable safety profileCox regression modelMulticenter international studyAnalysis inclusion criteriaBaseline imaging dataCVT patientsOral anticoagulationComplete recanalizationDOAC treatmentOral anticoagulantsRadiological outcomesRadiographic outcomesVersus WarfarinWarfarin treatmentEndovascular Treatment of Acute Stroke.
Giles JA, Vellimana AK, Adeoye OM. Endovascular Treatment of Acute Stroke. Current Neurology And Neuroscience Reports 2022, 22: 83-91. PMID: 35098425, DOI: 10.1007/s11910-022-01168-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Non-Vitamin K Antagonist Oral Anticoagulants for the Treatment of Cerebral Venous Sinus Thrombosis: a Retrospective, Matched Cohort Analysis.
Giles JA, Balasetti VKS, Zazulia AR. Non-Vitamin K Antagonist Oral Anticoagulants for the Treatment of Cerebral Venous Sinus Thrombosis: a Retrospective, Matched Cohort Analysis. Neurocritical Care 2021, 35: 783-788. PMID: 34046861, DOI: 10.1007/s12028-021-01244-x.Peer-Reviewed Original ResearchBlood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study
Petersen NH, Kodali S, Meng C, Li F, Nguyen CK, Peshwe KU, Strander S, Silverman A, Kimmel A, Wang A, Anadani M, Almallouhi E, Spiotta AM, Kim JT, Giles JA, Keyrouz SG, Farooqui M, Zevallos C, Maier IL, Psychogios MN, Liman J, Riou-Comte N, Richard S, Gory B, Wolfe S, Brown PA, Fargen KM, Mistry EA, Fakhri H, Mistry AM, Wong KH, de Havenon A, Nascimento FA, Kan P, Matouk C, Ortega-Gutiérrez S, Sheth KN. Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study. Stroke 2021, 53: 1216-1225. PMID: 34781705, PMCID: PMC8960326, DOI: 10.1161/strokeaha.121.034408.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSymptomatic intracranial hemorrhageEndovascular thrombectomyBlood pressure trajectoriesFunctional outcomeHemorrhagic transformationIschemic strokeSBP trajectoriesIntracranial hemorrhageAnterior circulation large vessel occlusion ischemic strokeModified Rankin Scale (mRS) 90 daysTrajectory groupsLarge vessel occlusion ischemic strokeMulticenter retrospective cohort studySystolic blood pressure trajectoriesBlood pressure courseOptimal hemodynamic managementSBP trajectory groupsRetrospective cohort studyAcute ischemic strokeElevated blood pressurePoor functional outcomePressure trajectoriesBlood pressure dataCohort studySecondary outcomesDifferential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke.
Akbik F, Alawieh A, Cawley CM, Howard BM, Tong FC, Nahab F, Saad H, Dimisko L, Mustroph C, Samuels OB, Pradilla G, Maier I, Goyal N, Starke RM, Rai A, Fargen KM, Psychogios MN, Jabbour P, De Leacy R, Giles J, Dumont TM, Kan P, Arthur AS, Crosa RJ, Gory B, Spiotta AM, Grossberg JA. Differential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke. Journal Of Neurointerventional Surgery 2021, 13: 883-888. PMID: 33318066, PMCID: PMC8377613, DOI: 10.1136/neurintsurg-2020-016720.Peer-Reviewed Original ResearchCentral Triage of Acute Stroke Patients Across a Distributive Stroke Network Is Safe and Reduces Transfer Denials.
Holder D, Leeseberg K, Giles JA, Lee JM, Namazie S, Ford AL. Central Triage of Acute Stroke Patients Across a Distributive Stroke Network Is Safe and Reduces Transfer Denials. Stroke; A Journal Of Cerebral Circulation 2021, 52: 2671-2675. PMID: 34154389, PMCID: PMC8316396, DOI: 10.1161/STROKEAHA.120.033018.Peer-Reviewed Original ResearchEffect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study
Yaghi S, Mistry E, de Havenon A, Guerrero C, Nouh A, Liberman AL, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini‐Naghani I, Siddu M, Scher E, Trivedi T, Wu T, Khan M, Keyrouz S, Furie K, Henninger N. Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study. Journal Of The American Heart Association 2021, 10: e020945. PMID: 34323120, PMCID: PMC8475683, DOI: 10.1161/jaha.121.020945.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute ischemic strokeMechanical thrombectomyAlteplase useIschemic strokeHemorrhagic transformationAtrial fibrillationPrimary analysisEfficacy of alteplaseInitiation of anticoagulationComprehensive stroke centerBinary logistic regressionIntravenous alteplaseStroke centersConsecutive patientsStroke StudyAlteplaseMortality ratePatientsSecondary analysisMortalityStrokeLogistic regressionFurther studiesFibrillationIAC studyIschaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study
Yaghi S, Henninger N, Giles JA, Guerrero C, Mistry E, Liberman AL, Asad D, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Furie KL, Keyrouz SG, Nouh A, de Havenon A, Khan M, Smith EE, Gurol ME. Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study. Journal Of Neurology Neurosurgery & Psychiatry 2021, 92: 1062-1067. PMID: 33903185, PMCID: PMC8448925, DOI: 10.1136/jnnp-2021-326166.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRecurrent ischemic eventsSymptomatic intracranial hemorrhageIschemic strokeIschemic eventsAtrial fibrillationAnticoagulation therapyAcute cardioembolic strokeAnticoagulation-naïve patientsInitiation of anticoagulationStroke prevention measuresComprehensive stroke centerIschemic stroke patientsAcute ischemic strokeCox regression analysisSecondary prevention strategiesCox hazard modelSICH riskAnticoagulant therapyAnticoagulation statusStroke centersCardioembolic strokeAF patientsConsecutive patientsEarly recurrenceIntracranial hemorrhage
2020
Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration.
Alawieh AM, Eid M, Anadani M, Sattur M, Maier IL, Feng W, Goyal N, Starke RM, Rai A, Fargen KM, Psychogios MN, De Leacy R, Grossberg JA, Keyrouz SG, Dumont TM, Kan P, Lena J, Liman J, Arthur AS, Elijovich L, Mccarthy DJ, Saini V, Wolfe SQ, Mocco J, Fifi JT, Nascimento FA, Giles JA, Allen M, Crosa R, Fox WC, Gory B, Spiotta AM. Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration. Neurosurgery 2020, 87: 982-991. PMID: 32433730, DOI: 10.1093/neuros/nyaa179.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
HIC ID2000031893RolePrincipal InvestigatorPrimary Completion Date03/07/2028Recruiting ParticipantsGenderBothAge30 years - 80 yearsBiomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
HIC ID2000031665RoleSub InvestigatorPrimary Completion Date12/01/2025Recruiting ParticipantsGenderBothAge18+ yearsRegulating Blood Pressure During Recovery from Intracerebral Hemorrhage and Ischemic Stroke (REDUCE)
HIC ID2000029811RoleSub InvestigatorPrimary Completion Date01/31/2025Recruiting ParticipantsGenderBothAge18+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
Activities
activity Junior & Early Career Committee, American Neurological Association
07/01/2021 - PresentProfessional OrganizationsMember
Clinical Care
Overview
James A. Giles, MD, PhD, is a vascular neurologist who specializes in the care of patients with cerebrovascular diseases, including ischemic and hemorrhagic strokes.
As an assistant professor at Yale School of Medicine, Dr. Giles's research interests lie in advancing stroke treatment and prevention, with a focus on translating scientific discoveries into clinical practice.
Dr. Giles completed his medical degree and a doctoral degree in neuroscience at The University of Manchester in the United Kingdom. He then completed his neurology residency and stroke fellowship at Washington University School of Medicine and a clinical research fellowship at Oxford University.
Clinical Specialties
Neurology; Stroke
Fact Sheets
Ischemic Stroke
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