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INFORMATION FOR

Andrew Tan, PhD

Research Scientist

Contact Information

Andrew Tan, PhD

Mailing Address

  • Neurology

    950 Campbell Avenue, Bldg 34 (127A)

    West Haven, CT 06516

    United States

Appointments

Biography

My research interests focus on spinal cord injury (SCI) pathology, particularly mechanisms underlying neuropathic pain and spastic movement disorders. My long-term goal is to identify and assess novel targets and strategies that can help restore normal function after SCI. My hope is that our efforts will eventually lead to more effective and safe clinical therapies.

As the Principal Investigator (PI) of US Federal awards and privately funded grants, I have applied my expertise toward managing the execution of a broad range of projects, and have developed strong collaborations with domestic and international teams. As an Associate Director of the Center for Neuroscience and Regeneration Research at the West Haven VA Medical Center, I currently supervise a wonderful team of students, postdocs, and junior faculty in our SCI/D research program. Our published research has utilized in vitro and in vivo approaches, including a combination of anatomical analyses, behavioral assessment, viral-based gene therapy, and whole-animal electrophysiological techniques.

Over the past decade, my team has laid the groundwork demonstrating that maladaptive dendritic spine remodeling within nociceptive or motor reflex circuits underlies SCI-induced hyperexcitability disorders, i.e., neuropathic pain and spasticity. This body of work has also demonstrated for the first time that the Rac1-PAK1 pathway is a key mechanism involved in maintaining chronic pain and spinal motor reflex dysfunction. A core implication of these insights is that dendritic spine profiles may serve as a morphological correlate for sensory-motor hyperexcitability disorders, and could be used to predict therapeutic-drug response. Recently, we pioneered the use of long-term, in vivo two-photon imaging assays that we now use to investigate the relationship between dendritic spine dynamics in the spinal dorsal horn and neuropathic pain.

LinkedIn Profile

ResearchGate

Neuroscience and Art Blog

Education & Training

  • Postdoctoral Associate
    Columbia University/The City College (CUNY) (2011)
  • Postdoctoral Fellow
    Yale University (2008)
  • PhD
    Stony Brook University (2006)
  • BS
    University of Rochester, Neuroscience (2001)

Honors & Recognition

AwardAwarding OrganizationDate
Travel Award, 12th World Congress on PainInternational Association for the Study of Pain (IASP)2008
Research Work Award, Public Education/Communication CommitteeSociety for Neuroscience2008
Keystone Symposia ScholarshipNINDS2005

Professional Service

OrganizationRoleDate
International Scholarly Research NetworkBoard Member2012 - Present
AVI Publishing Inc.Journalist and editorial service for commercial magazine2009 - 2012
Phase Five Communications Inc./Grey Healthcare GroupAuthor2008 - 2010

Departments & Organizations