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Generation of neuronal progenitors derived from induced pluripotent stem cells.

Expand our repository of induced pluripotent cells (iPSC) from normal individuals and patients with neurological & psychiatric disorders

  • Autism spectrum disorders
  • Tourette Syndrome
  • SCA13

Recapitulate the development of forebrain and other brain regions using the organoid approach

  • in vitro & after transplantation
  • tools to identify different CNS lineages

Perform cellular, molecular, genetic, epigenetic, and functional studies of undifferentiated/differentiated iPSC lines from patients and controls

Compare with postmortem human brain:

  • Single cell genomes and transcriptomes
  • Genomic engineering using CRISPR
  • Epigenetic analyses

Development of in vitro models for small molecules/drug screening for neuropsychiatric disorders