"Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids"
- July 28, 2022Source: YaleNews
Scientists studying non-inherited, or somatic, mutations in frozen post-mortem human brains have found that about 6% of brains are much more likely to accumulate large numbers of these mutations and that these “hypermutable” brains tend to be 40 years old or older.
- July 26, 2022Source: For all issues, please visit: https://us14.campaign-archive.com/home/?u=075d4cacc1c5196316109f2cd&id=0f44120434
Human Excitation and Inhibition
- April 27, 2021Source: Psychiatry Online
Using human-derived stem cells, researchers are now able to create stable and functional 3D constructs that mimic some aspects of brain development.
- March 19, 2021Source: Science Vol 371, Issue 6535
Fasching L, Jang Y, Tomasi S, Schreiner J, Tomasini L, Brady MV, Bae T, Sarangi V, Vasmatzis N, Wang Y, Szekely A, Fernandez TV, Leckman JF, Abyzov A, Vaccarino FM. Early developmental asymmetries in cell lineage trees in living individuals. Science. 2021 Mar 19. PMID: 33737484.
- March 18, 2021Source: YaleNews
Using skin cells harvested from two living humans, researchers in the lab of Yale’s Flora Vaccarino were able to track their cellular lineage by identifying tiny variations or mutations contained within the genomes of those cells.
- November 12, 2020
"SCELLECTOR: ranking amplification bias in single cells using shallow sequencing"
- July 13, 2020
"PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids"