Max Spurrell
he/him/his
About
Research
Publications
Featured Publications
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Chen J, Nieman L, Spurrell M, Jorgji V, Elmelech L, Richieri P, Xu K, Madhu R, Parikh M, Zamora I, Mehta A, Nabel C, Freeman S, Pirl J, Lu C, Meador C, Barth J, Sakhi M, Tang A, Sarkizova S, Price C, Fernandez N, Emanuel G, He J, Van Raay K, Reeves J, Yizhak K, Hofree M, Shih A, Sade-Feldman M, Boland G, Pelka K, Aryee M, Mino-Kenudson M, Gainor J, Korsunsky I, Hacohen N. Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nature Immunology 2024, 25: 644-658. PMID: 38503922, PMCID: PMC12096941, DOI: 10.1038/s41590-024-01792-2.Peer-Reviewed Original ResearchAnti-CD3 mAb treatment reshapes infiltrating T and β cells in the islets in autoimmune diabetes
Wu Y, Spurrell M, Lledó-Delgado A, Deng S, Wang D, Liu Y, Barkestani M, Perdigoto A, Herold K. Anti-CD3 mAb treatment reshapes infiltrating T and β cells in the islets in autoimmune diabetes. JCI Insight 2026, 11: e192755. PMID: 41574610, PMCID: PMC12892913, DOI: 10.1172/jci.insight.192755.Peer-Reviewed Original Research
2025
Batch correcting single-cell spatial transcriptomics count data with Crescendo improves visualization and detection of spatial gene patterns
Millard N, Chen J, Palshikar M, Pelka K, Spurrell M, Price C, He J, Hacohen N, Raychaudhuri S, Korsunsky I. Batch correcting single-cell spatial transcriptomics count data with Crescendo improves visualization and detection of spatial gene patterns. Genome Biology 2025, 26: 36. PMID: 40001084, PMCID: PMC11863647, DOI: 10.1186/s13059-025-03479-9.Peer-Reviewed Original Research
2023
Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.
Chen JH, Nieman LT, Spurrell M, Jorgji V, Richieri P, Xu KH, Madhu R, Parikh M, Zamora I, Mehta A, Nabel CS, Freeman SS, Pirl JD, Lu C, Meador CB, Barth JL, Sakhi M, Tang AL, Sarkizova S, Price C, Fernandez NF, Emanuel G, He J, Raay KV, Reeves JW, Yizhak K, Hofree M, Shih A, Sade-Feldman M, Boland GM, Pelka K, Aryee M, Korsunsky I, Mino-Kenudson M, Gainor JF, Hacohen N. Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response. BioRxiv 2023 PMID: 37066412, DOI: 10.1101/2023.04.04.535379.Peer-Reviewed Original Research
2022
Gene regulatory divergence amongst echinoderms underlies appearance of pigment cells in sea urchin development
Spurrell M, Oulhen N, Foster S, Perillo M, Wessel G. Gene regulatory divergence amongst echinoderms underlies appearance of pigment cells in sea urchin development. Developmental Biology 2022, 494: 13-25. PMID: 36519720, PMCID: PMC9870932, DOI: 10.1016/j.ydbio.2022.11.008.Peer-Reviewed Original Research
2020
Methodology for Whole Mount and Fluorescent RNA In Situ Hybridization in Echinoderms: Single, Double, and Beyond
Perillo M, Paganos P, Spurrell M, Arnone M, Wessel G. Methodology for Whole Mount and Fluorescent RNA In Situ Hybridization in Echinoderms: Single, Double, and Beyond. Methods In Molecular Biology 2020, 2219: 195-216. PMID: 33074542, PMCID: PMC7583651, DOI: 10.1007/978-1-0716-0974-3_12.ChaptersRegulation of dynamic pigment cell states at single-cell resolution
Perillo M, Oulhen N, Foster S, Spurrell M, Calestani C, Wessel G. Regulation of dynamic pigment cell states at single-cell resolution. ELife 2020, 9: e60388. PMID: 32812865, PMCID: PMC7455242, DOI: 10.7554/elife.60388.Peer-Reviewed Original Research