Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders
Lester KJ, Roberts S, Keers R, Coleman JR, Breen G, Wong CC, Xu X, Arendt K, Blatter-Meunier J, Bögels S, Cooper P, Creswell C, Heiervang ER, Herren C, Hogendoorn SM, Hudson JL, Krause K, Lyneham HJ, McKinnon A, Morris T, Nauta MH, Rapee RM, Rey Y, Schneider S, Schneider SC, Silverman WK, Smith P, Thastum M, Thirlwall K, Waite P, Wergeland GJ, Eley TC. Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders. The British Journal Of Psychiatry 2016, 208: 182-188. PMID: 26294368, PMCID: PMC4837384, DOI: 10.1192/bjp.bp.114.154997.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesAnxiety DisordersChildChild, PreschoolCognitive Behavioral TherapyFemaleGene-Environment InteractionGenotypeHumansMalePsychiatric Status Rating ScalesRemission InductionSerotonin Plasma Membrane Transport ProteinsTreatment OutcomeConceptsCognitive behavioral therapyCBT outcomeChild anxietyAnxiety disordersChild anxiety disordersMore positive outcomesShort-allele homozygotesPositive treatment outcomesPsychological therapiesDisorder outcomesPositive outcomesTreatment studiesHomogenous sampleMixed resultsAnxietyMixed effects modelsNon-significant effectTreatment outcomesCohort 2DisordersSignificant associationFuture studiesOutcomesAssociationTherapy