2023
The Relationship Between Acute Dissociative Effects Induced by Ketamine and Treatment Response in Adolescent Patients with Treatment-Resistant Depression
Lineham A, Avila-Quintero V, Bloch M, Dwyer J. The Relationship Between Acute Dissociative Effects Induced by Ketamine and Treatment Response in Adolescent Patients with Treatment-Resistant Depression. Journal Of Child And Adolescent Psychopharmacology 2023, 33: 20-26. PMID: 36799961, DOI: 10.1089/cap.2022.0086.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionDepression symptom improvementAcute dissociative symptomsAntidepressant responseSymptom improvementRapid-acting antidepressant agentsSignificant associationDissociative symptomsLikelihood of responseDissociation symptomsMagnitude of associationDissociative effectsKetamine groupPediatric patientsCrossover trialPediatric populationAntidepressant agentsKetamine responseAdolescent patientsAdult studiesDepression responseSecondary data analysisTreatment responseDepressive symptomsTrial design
2022
Surgical repair of nasal septal perforations: A systematic review and meta‐analysis
Fermin J, Bui R, McCoul E, Alt J, Avila‐Quintero V, Chang B, Yim M. Surgical repair of nasal septal perforations: A systematic review and meta‐analysis. International Forum Of Allergy & Rhinology 2022, 12: 1104-1119. PMID: 34978162, DOI: 10.1002/alr.22965.Peer-Reviewed Original ResearchConceptsNasal septal perforationEndonasal approachSurgical managementSurgical repairSeptal perforationSuccess rateElectronic database searchCINAHL Plus databasesMedian MINORS scoreRandom-effects modelUse of graftsEnglish-language studiesNSP repairPooled proportionInterposition graftMethodological IndexStudy criteriaPrimary diagnosisSurgical approachMINORS scoreInclusion criteriaOutcome measuresUnilateral flapModerate heterogeneityBilateral flapsThe effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis
Farhat LC, Flores JM, Behling E, Avila-Quintero VJ, Lombroso A, Cortese S, Polanczyk GV, Bloch MH. The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis. Molecular Psychiatry 2022, 27: 1562-1572. PMID: 35027679, DOI: 10.1038/s41380-021-01391-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildHumansMethylphenidateTreatment OutcomeConceptsFixed-dose trialAttention-deficit/hyperactivity disorderDose-limiting adverse eventsChildren/adolescentsAdverse eventsFlexible-dose trialTerms of efficacyClinical practiceHigh dosesFlexible dose designIntolerable adverse eventsHyperactivity disorderIncremental benefitLikelihood of discontinuationADHD symptomsLarge systematic reviewSchool-aged children/adolescentsFlexible titrationPotential long-term effectsSymptom controlTreatment discontinuationClinical outcomesStimulant dosesDaily dosesClinical guidelines