2015
Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet
Musumeci G, Castrogiovanni P, Castorina S, Imbesi R, Szychlinska M, Scuderi S, Loreto C, Giunta S. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain Research Bulletin 2015, 119: 12-18. PMID: 26444078, DOI: 10.1016/j.brainresbull.2015.09.010.Peer-Reviewed Original ResearchConceptsFrontal cortexHigh TrP dietDentate gyrusTrp dietBrain areasBrain-derived neurotrophic factor (BDNF) expressionBrain-derived neurotrophic factorHigh-tryptophan dietNeuroplasticity-related moleculesBDNF protein expressionNeurotrophic factor expressionHippocampal region CA1Normal aging processAge-related cognitive declineChronic dietDiet protectsTryptophan dietWestern blot analysisBDNF expressionBDNF increaseBDNF systemNeurotrophin levelsAge-related declineTrp intakeNeurotrophic factor
2013
Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning
D’Amico A, Scuderi S, Leggio G, Castorina A, Drago F, D’Agata V. Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning. Neurochemical Research 2013, 38: 2516-2523. PMID: 24100927, DOI: 10.1007/s11064-013-1164-3.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseCAMP response element-binding proteinNuclear transcription factor cAMP response element-binding proteinTranscription factor cAMP response element-binding proteinExtracellular signal-regulated kinase 1/2C-Jun N-terminal kinaseCREB phosphorylationSignal-regulated kinase 1/2Response element-binding proteinElement-binding proteinProtein kinaseDe novo synthesisKinase 1/2ERK signalingAkt activationBinding proteinPhosphorylationPhosphorylation levelsP38 phosphorylationGenetic backgroundKnockout mice displayNovo synthesisKinaseSynaptic functionAktDopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus
Castorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDopamine and cAMP-Regulated Phosphoprotein 32FibrinolysinGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHippocampusImmunohistochemistryLearningMaleMemoryMiceMice, KnockoutOncogene Protein v-aktPhosphorylationPrefrontal CortexReal-Time Polymerase Chain ReactionReceptors, Dopamine D3RNA, MessengerRNA, Ribosomal, 18STissue Plasminogen Activator