2015
Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes
Scuderi S, D’amico A, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V. Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes. Journal Of Molecular Neuroscience 2015, 56: 431-439. PMID: 25676032, DOI: 10.1007/s12031-015-0505-x.Peer-Reviewed Original ResearchConceptsIL-1 family membersDiabetic retinopathyIL-1αRetinal layersIL-1raIL-1βIL-1RIInvolvement of inflammationGanglion cell layerNew pharmacological approachesRetinal expression patternType 1 diabetesEffects of hyperglycemiaReceptor IL-1RIFamily membersCommon complicationDiabetic patientsDiabetic ratsProinflammatory cytokinesInflammatory processInterleukin-1βIntraperitoneal injectionRat modelInner plexiformIL-1RII
2014
Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain
Scuderi S, La Cognata V, Drago F, Cavallaro S, D′Agata V. Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain. BioMed Research International 2014, 2014: 690796. PMID: 25136611, PMCID: PMC4124806, DOI: 10.1155/2014/690796.Peer-Reviewed Original ResearchConceptsExtensive alternative splicingParkinson protein 2Parkin isoformsAutosomal recessive early-onset Parkinson's diseaseTranscriptomic diversificationRecessive early-onset Parkinson's diseaseEncoded proteinsAlternative splicingPrimary transcriptGene mutationsExpression patternsGene transcriptsHuman pathologiesSplice variantsParkin deficiencyAmino acidsProtein 2Early-onset Parkinson's diseaseSporadic Parkinson's diseaseIsoformsElectrophoretic mobilityOnset Parkinson's diseaseTranscriptsProteinJuvenile Parkinson's diseaseDavunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death
Scuderi S, D’Amico A, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D’Agata V. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. Journal Of Molecular Neuroscience 2014, 54: 395-404. PMID: 24488575, DOI: 10.1007/s12031-014-0244-4.Peer-Reviewed Original ResearchConceptsNAP treatmentRetinas of STZSingle intraocular injectionCaspase-3 expression levelsRetinal degenerative diseasesMAPK/ERK pathwayPhosphatidylinositol-3-kinase/Akt pathwayMitogen-activated protein kinase/extracellular signal-regulated protein kinaseDiabetes inductionDiabetic injuryDiabetic retinaSTZ injectionNeuroprotective effectsDiabetic modelIntraocular injectionPotent neuroprotectionDiabetic retinopathyVivo streptozotocinRetinal expressionProtein kinase/extracellular signal-regulated protein kinaseAmino acid peptideKinase/Akt pathwayP-AktP-ERKApoptosis markers
2013
PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways
Castorina A, Scuderi S, D’Amico A, Drago F, D’Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Experimental Cell Research 2013, 322: 108-121. PMID: 24246222, DOI: 10.1016/j.yexcr.2013.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorEnzyme ActivationGene Expression Regulation, NeoplasticMyelin Basic ProteinMyelin P0 ProteinMyelin ProteinsMyelin-Associated GlycoproteinOncogene Protein v-aktPhosphatidylinositol 3-KinasesPituitary Adenylate Cyclase-Activating PolypeptideRatsReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISchwann CellsSignal TransductionVasoactive Intestinal PeptideConceptsPI3K/AktMyelin proteinsMyelin markersVIP receptor antagonistMyelin-related proteinsStarvation-induced expressionCanonical PI3K/AktSpecific pathway inhibitorsRat Schwannoma cell lineReceptor-mediated activationPI3K inhibitorsPhosphorylation of AktNM PACAPPACAP6-38Underlying molecular mechanismsEndogenous PACAPPhosphorylated ERK 1/2Schwannoma cell lineReceptor antagonistPeripheral expressionMyelin gene expressionRat schwannoma cellsPharmacological approachesSer473 residueNormal serumAntiproliferative Effects of PACAP and VIP in Serum-Starved Glioma Cells
D’Amico A, Scuderi S, Saccone S, Castorina A, Drago F, D’Agata V. Antiproliferative Effects of PACAP and VIP in Serum-Starved Glioma Cells. Journal Of Molecular Neuroscience 2013, 51: 503-513. PMID: 23900722, DOI: 10.1007/s12031-013-0076-7.Peer-Reviewed Original ResearchConceptsPituitary adenylate cyclase-activating polypeptideVasoactive intestinal peptideCalorie restrictionGlioma cellsCell proliferationEffects of PACAPAdenylate cyclase-activating polypeptideCyclase-activating polypeptideExpression of p53Expression of nestinFormation of metastasesC6 glioma cellsIntestinal peptideAcute conditionsVIP treatmentPrognostic markerExpression of proteinsCell malignanciesGFAP decreasesTumor microenvironmentAntiproliferative effectsCyclin D1Cancer developmentCancer treatmentCancer cells
2012
Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells
Castorina A, Giunta S, Scuderi S, D’Agata V. Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells. Journal Of Molecular Neuroscience 2012, 48: 674-683. PMID: 22454142, DOI: 10.1007/s12031-012-9755-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCulture Media, Serum-FreeDNA ReplicationDNA, NeoplasmDose-Response Relationship, DrugGene Expression Regulation, NeoplasticHydrogen PeroxideNeoplasm ProteinsNerve Sheath NeoplasmsNerve Tissue ProteinsPituitary Adenylate Cyclase-Activating PolypeptideRatsReal-Time Polymerase Chain ReactionReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISignal TransductionTumor Cells, CulturedConceptsMalignant peripheral nerve sheath tumorActivity-dependent neuroprotective proteinMPNST cellsNormal serumSS cellsADNP expressionMalignant peripheral nerve sheath tumor cellsPeripheral nerve sheath tumorsNerve sheath tumorsCyclase-activating polypeptideVPAC receptor antagonistSheath tumorsReceptor antagonistNeuroprotective proteinTumor cellsSerum starvationMetabolic stressCaspase-3DeathCell viabilityDNA fragmentationInvolvementCell resistanceCellsSurvival response