2013
PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways
Castorina A, Scuderi S, D’Amico A, Drago F, D’Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Experimental Cell Research 2013, 322: 108-121. PMID: 24246222, DOI: 10.1016/j.yexcr.2013.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorEnzyme ActivationGene Expression Regulation, NeoplasticMyelin Basic ProteinMyelin P0 ProteinMyelin ProteinsMyelin-Associated GlycoproteinOncogene Protein v-aktPhosphatidylinositol 3-KinasesPituitary Adenylate Cyclase-Activating PolypeptideRatsReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISchwann CellsSignal TransductionVasoactive Intestinal PeptideConceptsPI3K/AktMyelin proteinsMyelin markersVIP receptor antagonistMyelin-related proteinsStarvation-induced expressionCanonical PI3K/AktSpecific pathway inhibitorsRat Schwannoma cell lineReceptor-mediated activationPI3K inhibitorsPhosphorylation of AktNM PACAPPACAP6-38Underlying molecular mechanismsEndogenous PACAPPhosphorylated ERK 1/2Schwannoma cell lineReceptor antagonistPeripheral expressionMyelin gene expressionRat schwannoma cellsPharmacological approachesSer473 residueNormal serum
2012
Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells
Castorina A, Giunta S, Scuderi S, D’Agata V. Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells. Journal Of Molecular Neuroscience 2012, 48: 674-683. PMID: 22454142, DOI: 10.1007/s12031-012-9755-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCulture Media, Serum-FreeDNA ReplicationDNA, NeoplasmDose-Response Relationship, DrugGene Expression Regulation, NeoplasticHydrogen PeroxideNeoplasm ProteinsNerve Sheath NeoplasmsNerve Tissue ProteinsPituitary Adenylate Cyclase-Activating PolypeptideRatsReal-Time Polymerase Chain ReactionReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISignal TransductionTumor Cells, CulturedConceptsMalignant peripheral nerve sheath tumorActivity-dependent neuroprotective proteinMPNST cellsNormal serumSS cellsADNP expressionMalignant peripheral nerve sheath tumor cellsPeripheral nerve sheath tumorsNerve sheath tumorsCyclase-activating polypeptideVPAC receptor antagonistSheath tumorsReceptor antagonistNeuroprotective proteinTumor cellsSerum starvationMetabolic stressCaspase-3DeathCell viabilityDNA fragmentationInvolvementCell resistanceCellsSurvival response