PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways
Castorina A, Scuderi S, D’Amico A, Drago F, D’Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: Involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Experimental Cell Research 2013, 322: 108-121. PMID: 24246222, DOI: 10.1016/j.yexcr.2013.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorEnzyme ActivationGene Expression Regulation, NeoplasticMyelin Basic ProteinMyelin P0 ProteinMyelin ProteinsMyelin-Associated GlycoproteinOncogene Protein v-aktPhosphatidylinositol 3-KinasesPituitary Adenylate Cyclase-Activating PolypeptideRatsReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISchwann CellsSignal TransductionVasoactive Intestinal PeptideConceptsPI3K/AktMyelin proteinsMyelin markersVIP receptor antagonistMyelin-related proteinsStarvation-induced expressionCanonical PI3K/AktSpecific pathway inhibitorsRat Schwannoma cell lineReceptor-mediated activationPI3K inhibitorsPhosphorylation of AktNM PACAPPACAP6-38Underlying molecular mechanismsEndogenous PACAPPhosphorylated ERK 1/2Schwannoma cell lineReceptor antagonistPeripheral expressionMyelin gene expressionRat schwannoma cellsPharmacological approachesSer473 residueNormal serumDopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus
Castorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDopamine and cAMP-Regulated Phosphoprotein 32FibrinolysinGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHippocampusImmunohistochemistryLearningMaleMemoryMiceMice, KnockoutOncogene Protein v-aktPhosphorylationPrefrontal CortexReal-Time Polymerase Chain ReactionReceptors, Dopamine D3RNA, MessengerRNA, Ribosomal, 18STissue Plasminogen Activator