2013
Antiproliferative Effects of PACAP and VIP in Serum-Starved Glioma Cells
D’Amico A, Scuderi S, Saccone S, Castorina A, Drago F, D’Agata V. Antiproliferative Effects of PACAP and VIP in Serum-Starved Glioma Cells. Journal Of Molecular Neuroscience 2013, 51: 503-513. PMID: 23900722, DOI: 10.1007/s12031-013-0076-7.Peer-Reviewed Original ResearchConceptsPituitary adenylate cyclase-activating polypeptideVasoactive intestinal peptideCalorie restrictionGlioma cellsCell proliferationEffects of PACAPAdenylate cyclase-activating polypeptideCyclase-activating polypeptideExpression of p53Expression of nestinFormation of metastasesC6 glioma cellsIntestinal peptideAcute conditionsVIP treatmentPrognostic markerExpression of proteinsCell malignanciesGFAP decreasesTumor microenvironmentAntiproliferative effectsCyclin D1Cancer developmentCancer treatmentCancer cells
2012
Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells
Castorina A, Giunta S, Scuderi S, D’Agata V. Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells. Journal Of Molecular Neuroscience 2012, 48: 674-683. PMID: 22454142, DOI: 10.1007/s12031-012-9755-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCulture Media, Serum-FreeDNA ReplicationDNA, NeoplasmDose-Response Relationship, DrugGene Expression Regulation, NeoplasticHydrogen PeroxideNeoplasm ProteinsNerve Sheath NeoplasmsNerve Tissue ProteinsPituitary Adenylate Cyclase-Activating PolypeptideRatsReal-Time Polymerase Chain ReactionReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISignal TransductionTumor Cells, CulturedConceptsMalignant peripheral nerve sheath tumorActivity-dependent neuroprotective proteinMPNST cellsNormal serumSS cellsADNP expressionMalignant peripheral nerve sheath tumor cellsPeripheral nerve sheath tumorsNerve sheath tumorsCyclase-activating polypeptideVPAC receptor antagonistSheath tumorsReceptor antagonistNeuroprotective proteinTumor cellsSerum starvationMetabolic stressCaspase-3DeathCell viabilityDNA fragmentationInvolvementCell resistanceCellsSurvival response