2013
Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP
Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR. Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP. Neuropsychopharmacology 2013, 39: 569-578. PMID: 23989619, PMCID: PMC3895235, DOI: 10.1038/npp.2013.229.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexCocaineCorpus StriatumDopamine Uptake InhibitorsEnzyme InhibitorsGene Expression RegulationHumansIn Vitro TechniquesInhibitory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLMice, KnockoutNeural PathwaysNeuronsProtein Tyrosine Phosphatases, Non-ReceptorReceptor, Adenosine A2ASynaptic TransmissionSynaptosomesVanadatesConceptsEffects of cocaineSynaptic transmissionAdenosine A2A receptorsStriatal-enriched protein tyrosine phosphatasePharmacological actionsA2A receptorsWhole-cell voltage-clamp recordingsA2AR antagonist ZM241385Excitatory post-synaptic currentsCocaine-induced reductionMedium spiny neuronsCocaine-induced changesVoltage-clamp recordingsPost-synaptic currentsA2AR knockout miceCorticostriatal slicesStriatal slicesPsychomotor effectsSpiny neuronsSynaptic mechanismsAntagonist ZM241385Synaptic depressionClamp recordingsBrain areasStriatum
2011
Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity
Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E. Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity. Journal Of Neuroscience 2011, 31: 8150-8162. PMID: 21632937, PMCID: PMC3472648, DOI: 10.1523/jneurosci.3446-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCalcineurinCell DeathDisease Models, AnimalGene Expression RegulationGene Products, tatHuntingtin ProteinHuntington DiseaseMiceMice, Neurologic MutantsMice, TransgenicMicroinjectionsNerve Tissue ProteinsNuclear ProteinsPhosphorylationProtein Tyrosine Phosphatases, Non-ReceptorQuinolinic AcidSignal TransductionConceptsStriatal-enriched protein tyrosine phosphataseCell deathSTEP expressionPhosphorylation levelsProtein Tyrosine Phosphatase ExpressionProtein tyrosine phosphataseSTEP phosphorylationTyrosine phosphataseProtein kinasePhosphorylated ERK2Phosphatase expressionHuntington's diseaseSTEP proteinMutant huntingtinCalcineurin activityPhosphorylationExon 1STEP protein levelsDisease mouse modelProtein levelsMouse modelMouse striatumTAT-STEPHuntington's disease mouse modelExpression
2001
Genetics of Childhood Disorders: XXX. Autoimmune Disorders, Part 3: Myasthenia Gravis and Rasmussen's Encephalitis
LOMBROSO P, MERCADANTE M, Lombroso P. Genetics of Childhood Disorders: XXX. Autoimmune Disorders, Part 3: Myasthenia Gravis and Rasmussen's Encephalitis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 1115-1117. PMID: 11556637, DOI: 10.1097/00004583-200109000-00022.Peer-Reviewed Original ResearchGenetics of Childhood Disorders: XXV. Velocardiofacial Syndrome
GOTHELF D, LOMBROSO P. Genetics of Childhood Disorders: XXV. Velocardiofacial Syndrome. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 489-491. PMID: 11314577, DOI: 10.1097/00004583-200104000-00021.Peer-Reviewed Original Research
2000
The Genetics of Childhood Psychiatric Disorders: A Decade of Progress
STATE M, LOMBROSO P, PAULS D, LECKMAN J. The Genetics of Childhood Psychiatric Disorders: A Decade of Progress. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 946-962. PMID: 10939224, DOI: 10.1097/00004583-200008000-00006.Peer-Reviewed Original ResearchGenetics of Childhood Disorders: XVI. Angelman Syndrome: A Failure to Process
LOMBROSO P, Lombroso P. Genetics of Childhood Disorders: XVI. Angelman Syndrome: A Failure to Process. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 931-933. PMID: 10892237, DOI: 10.1097/00004583-200007000-00024.Peer-Reviewed Original ResearchGenetics of Childhood Disorders: XV. Prader-Willi Syndrome: Genes, Brain, and Behavior
STATE M, DYKENS E, Lombroso P. Genetics of Childhood Disorders: XV. Prader-Willi Syndrome: Genes, Brain, and Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 797-800. PMID: 10846317, DOI: 10.1097/00004583-200006000-00021.Peer-Reviewed Original ResearchGenetics of Childhood Disorders: XIII. Genomic Imprinting: The Indelible Mark of the Gamete
GREALLY J, STATE M, Lombroso P. Genetics of Childhood Disorders: XIII. Genomic Imprinting: The Indelible Mark of the Gamete. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 532-535. PMID: 10761358, DOI: 10.1097/00004583-200004000-00025.Peer-Reviewed Original Research
1999
Genetics of Childhood Disorders: IV. Linkage Analysis
Lombroso P, PAULS D. Genetics of Childhood Disorders: IV. Linkage Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 932-934. PMID: 10405513, DOI: 10.1097/00004583-199907000-00025.Peer-Reviewed Original Research