2009
Heterogeneity and Homogeneity Across the Autism Spectrum: The Role of Development
Lombroso P, Ogren M, Jones W, Klin A. Heterogeneity and Homogeneity Across the Autism Spectrum: The Role of Development. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 471-473. PMID: 19395902, DOI: 10.1097/chi.0b013e31819f6c0d.Peer-Reviewed Original Research
2006
The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala
Paul S, Olausson P, Venkitaramani DV, Ruchkina I, Moran TD, Tronson N, Mills E, Hakim S, Salter MW, Taylor JR, Lombroso PJ. The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala. Biological Psychiatry 2006, 61: 1049-1061. PMID: 17081505, PMCID: PMC1853327, DOI: 10.1016/j.biopsych.2006.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAminoacetonitrileAmygdalaAnimalsBehavior, AnimalCells, CulturedConditioning, ClassicalCycloheximideElectric StimulationEnzyme InhibitorsFearFemaleImmunohistochemistryIn Vitro TechniquesLong-Term PotentiationMemoryMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NeostriatumPatch-Clamp TechniquesPoint MutationPregnancyProtein Synthesis InhibitorsProtein Tyrosine PhosphatasesRatsRats, Sprague-DawleyTranslocation, GeneticConceptsStriatal-enriched protein tyrosine phosphataseERK1/2 activationMitogen-activated protein kinaseProtein tyrosine phosphataseDe novo translationActivation of ERK1/2Tyrosine phosphataseProtein bindsKinase signalingProtein kinaseSequential recruitmentAmygdala-dependent memory formationERK pathwayMemory formationPrimary cell culturesNuclear translocationBiphasic activationLong-term potentiationTranslation blockTAT-STEPERKCell culturesERK1/2ActivationPathway
2002
Genetics of Childhood Disorders: XLI. Stem Cell Research, Part 5: Ethical Questions
OUTKA G, Lombroso P. Genetics of Childhood Disorders: XLI. Stem Cell Research, Part 5: Ethical Questions. Journal Of The American Academy Of Child & Adolescent Psychiatry 2002, 41: 1017-1019. PMID: 12162620, DOI: 10.1097/00004583-200208000-00023.Peer-Reviewed Original Research
2001
Genetics of Childhood Disorders: XXXI. Autoimmune Disorders, Part 4: Is Sydenham Chorea an Autoimmune Disorder?
LOISELLE C, SINGER H, Lombroso P. Genetics of Childhood Disorders: XXXI. Autoimmune Disorders, Part 4: Is Sydenham Chorea an Autoimmune Disorder? Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 1234-1236. PMID: 11589538, DOI: 10.1097/00004583-200110000-00019.Peer-Reviewed Original ResearchAntibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controlsThermal Sensitivity in Tourette Syndrome: Preliminary Report
Scahill L, Lombroso P, Mack G, Van Wattum P, Zhang H, Vitale A, Leckman J. Thermal Sensitivity in Tourette Syndrome: Preliminary Report. Perceptual And Motor Skills 2001, 92: 419-432. PMID: 11361302, DOI: 10.2466/pms.2001.92.2.419.Peer-Reviewed Original ResearchConceptsTourette syndromeSubgroup of patientsAge of onsetAdult male subjectsCurrent ageTic symptomsDopaminergic pathwaysSex distributionCurrent severityMale subjectsMean differenceSyndromeControl periodPreliminary reportSweat rateAgeSymptomsSubjectsOverall courseDegrees COnsetPatientsIllnessSeverityCourse
2000
Genetics of Childhood Disorders: XVIII. ADHD, Part 2: Norepinephrine Has a Critical Modulatory Influence on Prefrontal Cortical Function
ARNSTEN A, Lombroso P. Genetics of Childhood Disorders: XVIII. ADHD, Part 2: Norepinephrine Has a Critical Modulatory Influence on Prefrontal Cortical Function. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 1201-1203. PMID: 10986819, DOI: 10.1097/00004583-200009000-00022.Peer-Reviewed Original ResearchGenetics of Childhood Disorders: XVI. Angelman Syndrome: A Failure to Process
LOMBROSO P, Lombroso P. Genetics of Childhood Disorders: XVI. Angelman Syndrome: A Failure to Process. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 931-933. PMID: 10892237, DOI: 10.1097/00004583-200007000-00024.Peer-Reviewed Original Research
1999
Hypoxia‐Ischemia in Perinatal Rat Brain Induces the Formation of a Low Molecular Weight Isoform of Striatal Enriched Tyrosine Phosphatase (STEP)
Gurd J, Bissoon N, Nguyen T, Lombroso P, Rider C, Beesley P, Vannucci S. Hypoxia‐Ischemia in Perinatal Rat Brain Induces the Formation of a Low Molecular Weight Isoform of Striatal Enriched Tyrosine Phosphatase (STEP). Journal Of Neurochemistry 1999, 73: 1990-1994. PMID: 10537057, DOI: 10.1046/j.1471-4159.1999.01990.x.Peer-Reviewed Original ResearchConceptsHypoxia-ischemiaP21 ratsRat brainIschemia-induced elevationP21 rat brainUnilateral hypoxia-ischemiaCerebral hypoxia-ischemiaPerinatal rat brainResult of ischemiaCalcium-dependent proteolysisLow molecular weight isoformsInterval of recoveryP7 ratsContralateral sideMolecular weight isoformsNT2/D1 cellsCalcium ionophoreLow Mr isoformPostsynaptic densityRatsBrainCalpain IWeight isoformsIschemiaPhosphorylation levelsCalcium‐Dependent Cleavage of Striatal Enriched Tyrosine Phosphatase (STEP)
Nguyen T, Paul S, Xu Y, Gurd J, Lombroso P. Calcium‐Dependent Cleavage of Striatal Enriched Tyrosine Phosphatase (STEP). Journal Of Neurochemistry 1999, 73: 1995-2001. PMID: 10537058, DOI: 10.1046/j.1471-4159.1999.01995.x.Peer-Reviewed Original ResearchConceptsPostsynaptic densityTransient hypoxia-ischemiaPrimary neuronal culturesNeuronal precursor cellsCalcium-dependent cleavageHypoxia-ischemiaStriatal neuronsNeuronal insultsRat striatumNeuronal culturesCalcium ionophoreCalpain inhibitorsSTEP61Precursor cellsLow molecular weight formMolecular weight formsPhosphorylation levelsSmaller isoformSignificant increaseTyrosine phosphorylation levelsRapid appearanceCalpain treatmentRapid influxWeight formsCellsGenetics of Childhood Disorders: IV. Linkage Analysis
Lombroso P, PAULS D. Genetics of Childhood Disorders: IV. Linkage Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 932-934. PMID: 10405513, DOI: 10.1097/00004583-199907000-00025.Peer-Reviewed Original Research
1997
STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms.
Bult A, Zhao F, Dirkx R, Raghunathan A, Solimena M, Lombroso P. STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms. European Journal Of Cell Biology 1997, 72: 337-44. PMID: 9127733.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBlotting, WesternBrainCalcium-Binding ProteinsCalnexinCHO CellsCricetinaeFemaleFluorescent Antibody Technique, IndirectMembrane ProteinsMolecular Sequence DataProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorRatsSynaptophysinTransfectionConceptsProtein tyrosine phosphataseCatalytic phosphatase domainProtein tyrosine kinase familyHydrophobic amino acid sequenceAlternative splicing mechanismAmino acid sequencePrevious biochemical studiesTyrosine kinase familyStop codon upstreamPhosphatase domainCytosolic variantAlternative splicingMembrane compartmentsTyrosine phosphataseKinase familySplicing mechanismSubcellular localizationCytosolic proteinsAcid sequenceN-terminusInactive variantContinuous sucrose gradientSTEP isoformsPolyproline domainEndoplasmic reticulum
1996
A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified
TUCKER D, LECKMAN J, SCAHILL L, WILF G, LaCAMERA R, CARDONA L, COHEN P, HEIDMANN S, GOLDSTEIN J, JUDGE J, SNYDER E, BULT A, PETERSON B, KING R, LOMBROSO P. A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1684-1691. PMID: 8973076, DOI: 10.1097/00004583-199612000-00022.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersSelective serotonin reuptake inhibitorsSessions of plasmapheresisSerotonin reuptake inhibitorsUpper respiratory symptomsTreatment-resistant casesClinical laboratory dataCognitive behavioral therapyNeuroimmunological perspectiveProphylactic penicillinRespiratory symptomsReuptake inhibitorsObsessive-compulsive disorderConventional pharmacotherapyTreatment optionsSupportive psychotherapyFamily interventionsSeparation anxietyLaboratory dataSubsequent treatmentDisordersPsychotherapyMultiple perspectivesPharmacotherapyTransient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum
Raghunathan A, Matthews G, Lombroso P, Naegele J. Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum. Brain Research 1996, 91: 190-199. PMID: 8852369, DOI: 10.1016/0165-3806(95)00176-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, NorthernBlotting, WesternCalbindinsCell CountDopamine and cAMP-Regulated Phosphoprotein 32Enzyme InhibitorsFemaleGene Expression Regulation, DevelopmentalIsoenzymesNeostriatumNerve Tissue ProteinsNeuronsPhosphoproteinsPostpartum PeriodPregnancyProtein Tyrosine PhosphatasesRatsRats, Inbred StrainsS100 Calcium Binding Protein GSubstance PSubstantia NigraTime FactorsTranscription, GeneticConceptsPatch neuronsPostnatal weekTwo-color immunofluorescent stainingTyrosine hydroxylase-immunoreactive fibersDopaminoceptive brain regionsCalbindin-positive neuronsHydroxylase-immunoreactive fibersStriatum of ratsDopamine islandsPostnatal day 1Most striatal neuronsFirst postnatal weekEarly postnatal developmentMatrix neuronsStriatal afferentsStriatal neuronsImmunoreactive fibersSubstance PLateral striatumDay 1StriatumPostnatal developmentBrain regionsNeuronsCompartmental expression
1995
Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gain
1993
A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures
Lombroso P, Naegele, Sharma E, Lerner M. A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures. Journal Of Neuroscience 1993, 13: 3064-3074. PMID: 8331384, PMCID: PMC6576687, DOI: 10.1523/jneurosci.13-07-03064.1993.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaBase SequenceBlotting, WesternBrainChromatography, AffinityCorpus StriatumDopamine and cAMP-Regulated Phosphoprotein 32FemaleGene ExpressionImmune SeraImmunohistochemistryKineticsMaleMolecular Sequence DataMolecular WeightNerve Tissue ProteinsNeuronsOligodeoxyribonucleotidesOligonucleotides, AntisenseOrgan SpecificityPhosphoproteinsPolymerase Chain ReactionProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorRatsReceptors, DopamineRecombinant Fusion Proteins
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms