2003
Receptor and nonreceptor protein tyrosine phosphatases in the nervous system
Paul S, Lombroso P. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cellular And Molecular Life Sciences 2003, 60: 2465-2482. PMID: 14625689, PMCID: PMC11138652, DOI: 10.1007/s00018-003-3123-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainHumansIntracellular Signaling Peptides and ProteinsMitogen-Activated Protein KinasesNerve Tissue ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorReceptor-Like Protein Tyrosine Phosphatases, Class 2Receptor-Like Protein Tyrosine Phosphatases, Class 5Receptors, Cell SurfaceSignal TransductionConceptsProtein tyrosineNonreceptor protein tyrosineDual-specific phosphataseCellular signaling pathwaysNervous systemSignaling pathwaysCellular localizationPhysiological functionsFunctional rolePTPCentral nervous systemIntracellular mechanismsTyrosineImportant rolePhosphatasePathwayRoleLocalizationFunctionReceptors
1996
STEP61: A Member of a Family of Brain-Enriched PTPs Is Localized to the Endoplasmic Reticulum
Bult A, Zhao F, Dirkx R, Sharma E, Lukacsi E, Solimena M, Naegele J, Lombroso P. STEP61: A Member of a Family of Brain-Enriched PTPs Is Localized to the Endoplasmic Reticulum. Journal Of Neuroscience 1996, 16: 7821-7831. PMID: 8987810, PMCID: PMC6579237, DOI: 10.1523/jneurosci.16-24-07821.1996.Peer-Reviewed Original ResearchConceptsNovel N-terminal regionEnzymatic activityEndoplasmic reticulumPutative transmembrane domainsIntrinsic membrane proteinsExtended N-terminusAmino acid sequenceN-terminal regionDistinctive intracellular distributionsProtein tyrosineCytosolic variantTransmembrane domainMembrane compartmentsMembrane proteinsAcid sequenceSubcellular fractionationN-terminusRecombinant proteinsTransfection experimentsSTEP61Intracellular distributionProteinReticulumImmunocytochemical labelingFamily
1995
Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases
Sharma E, Zhao F, Bult A, Lombroso P. Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases. Brain Research 1995, 32: 87-93. PMID: 7494467, DOI: 10.1016/0169-328x(95)00066-2.Peer-Reviewed Original ResearchConceptsTyrosine phosphatase domainPhosphatase domainProtein tyrosineSpliced transcriptsExon-intron organizationProtein tyrosine phosphataseOpen reading frameTyrosine phosphataseReading frameDistinct functionsGenomic DNANorthern analysisSTEP geneSTEP isoformsMolecular massTranscriptsSTEP61ProteinMouse brainTyrosineCentral nervous systemSubfamiliesGenesNervous systemMonoclonal antibodies
1994
Protein tyrosine phosphatases in the nervous system.
Naegele J, Lombroso P. Protein tyrosine phosphatases in the nervous system. Critical Reviews In Neurobiology 1994, 9: 105-14. PMID: 8828006.Peer-Reviewed Original ResearchConceptsGrowth factor receptor signaling cascadesTyrosine kinaseReceptor signaling cascadesRole of PTPsNervous systemProtein tyrosineNeuronal developmentLevels of phosphotyrosineBrainEvidence pointsSignaling cascadesFunctional roleTyrosine phosphataseLocalization patternsNeurotransmittersImportant role