ACE Insertion/Deletion Genotype Affects Bradykinin Metabolism
Brown N, Blais C, Gandhi S, Adam A. ACE Insertion/Deletion Genotype Affects Bradykinin Metabolism. Journal Of Cardiovascular Pharmacology 1998, 32: 373-377. PMID: 9733349, DOI: 10.1097/00005344-199809000-00006.Peer-Reviewed Original ResearchConceptsSerum ACE activityAng IIACE activityPlasma Ang II concentrationACE insertion/deletion genotypeACE deletion alleleAng I infusionAng II concentrationsDeleterious cardiovascular effectsACE D alleleInsertion/deletion genotypeSignificant inverse relationACE deletionCardiovascular morbidityCardiovascular effectsI infusionAng IACE genotypeACE levelsACE DDBradykinin degradationAngiotensin ID alleleSynthetic bradykininDeletion alleleGender Affects Renal Vasoconstrictor Response to Ang I and Ang II
Gandhi S, Gainer J, King D, Brown N. Gender Affects Renal Vasoconstrictor Response to Ang I and Ang II. Hypertension 1998, 31: 90-96. PMID: 9449397, DOI: 10.1161/01.hyp.31.1.90.Peer-Reviewed Original ResearchConceptsRenal vasoconstrictor responsesAng II levelsAng IAng IIVasoconstrictor responsesPressor responseII levelsHeart rateAng I infusionPlasma renin activityAng II infusionBaseline blood pressureMean arterial pressureAng II concentrationsRenal plasma flowII infusionRenin activitySodium excretionAngiotensin infusionNormotensive subjectsArterial pressureBlood pressureCrossover studyI infusionACE activity