Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Vander Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudateSystematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders
Reichow B, Volkmar FR, Bloch MH. Systematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2013, 43: 2435-2441. PMID: 23468071, PMCID: PMC3787525, DOI: 10.1007/s10803-013-1793-z.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderADHD symptomsTrial of atomoxetineHyperactivity disorderPlacebo-controlled trialEfficacy of medicationsAdverse eventsPharmacological treatmentMethylphenidate trialMeta-AnalysisSystematic reviewSymptomsPervasive developmental disorderTrialsRelative efficacyIndividual trialsMedicationsDisordersChildrenDevelopmental disordersEfficacyPDDRandom effectsPlaceboClonidine