2019
Trim the fat: the role of omega-3 fatty acids in psychopharmacology
Nasir M, Bloch MH. Trim the fat: the role of omega-3 fatty acids in psychopharmacology. Therapeutic Advances In Psychopharmacology 2019, 9: 2045125319869791. PMID: 31489174, PMCID: PMC6713969, DOI: 10.1177/2045125319869791.Peer-Reviewed Original ResearchPost-traumatic stress disorderDepressive disorderAmerican Psychiatric AssociationFindings of RCTsRecent negative studiesSide effect profileFatty acid supplementationFatty acidsRandomized-controlled trialEvidence of efficacySubstantial methodological shortcomingsEvidence-based treatmentsImpulse control disordersIncomplete blindingHeterogeneous sample populationsBipolar maniaTreatment guidelinesCurrent guidelinesCardiovascular diseaseAcid supplementationNegative studiesPatient complianceUnipolar depressionIneffective treatmentPsychotic disorders
2014
Nutritional Supplements for the Treatment of ADHD
Bloch MH, Mulqueen J. Nutritional Supplements for the Treatment of ADHD. Child And Adolescent Psychiatric Clinics Of North America 2014, 23: 883-897. PMID: 25220092, PMCID: PMC4170184, DOI: 10.1016/j.chc.2014.05.002.Peer-Reviewed Original ResearchConceptsSide effectsNatural supplementsFatty acid supplementationADHD symptomsCore ADHD symptomsPossible side effectsTreatment of ADHDChronic insomniaADHD treatmentAcid supplementationModest benefitPotential efficacyNutritional supplementsHerbal remediesScientific evidenceMinimal evidenceSymptomsEfficacySupplements
2012
Meta-analysis of Long-Chain Polyunsaturated Fatty Acid Supplementation of Formula and Infant Cognition
Qawasmi A, Landeros-Weisenberger A, Leckman JF, Bloch MH. Meta-analysis of Long-Chain Polyunsaturated Fatty Acid Supplementation of Formula and Infant Cognition. Pediatrics 2012, 129: 1141-1149. PMID: 22641753, PMCID: PMC3362904, DOI: 10.1542/peds.2011-2127.Peer-Reviewed Original ResearchConceptsLCPUFA supplementationClinical trialsInfant formulaLong-Chain Polyunsaturated Fatty Acid SupplementationBayley ScalesPolyunsaturated Fatty Acid SupplementationTrial methodologic qualityInfants fed formulaWeighted mean differenceSecondary subgroup analysisFatty acid supplementationMeasures of neurodevelopmentInfant Development scoresFed formulaPrimary outcomeSubgroup analysisUnsupplemented formulaMethodologic qualityInclusion criteriaPrematurity statusAcid supplementationSupplementation efficacySecondary analysisPublication biasMean difference
2011
Omega-3 Fatty Acid Supplementation for the Treatment of Children With Attention-Deficit/Hyperactivity Disorder Symptomatology: Systematic Review and Meta-Analysis
Bloch MH, Qawasmi A. Omega-3 Fatty Acid Supplementation for the Treatment of Children With Attention-Deficit/Hyperactivity Disorder Symptomatology: Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2011, 50: 991-1000. PMID: 21961774, PMCID: PMC3625948, DOI: 10.1016/j.jaac.2011.06.008.Peer-Reviewed Original ResearchConceptsFatty acid supplementationAttention-deficit/hyperactivity disorderAcid supplementationOmega-3 Fatty Acid SupplementationTreatment of ADHDRandomized placebo-controlled trialBenign side effect profilePlacebo-controlled trialSide effect profilePrimary outcome measurementAnti-inflammatory propertiesTreatment of childrenCell membrane fluidityEffect of dosingAvailable pharmacotherapiesFatty acidsModest efficacyPharmacologic interventionsHyperactivity disorder symptomatologyOutcome measurementsDopamine neurotransmissionAcid doseHigh dosesPsychopharmacologic optionsMeta-Analysis