2021
Meta-Analysis: Pediatric Placebo Response in Depression Trials Does Not Replicate in Anxiety and Obsessive-Compulsive Disorder Trials
Nasir M, Li F, Courley S, Olten B, Bloch MH. Meta-Analysis: Pediatric Placebo Response in Depression Trials Does Not Replicate in Anxiety and Obsessive-Compulsive Disorder Trials. Journal Of Child And Adolescent Psychopharmacology 2021, 31: 670-684. PMID: 34558984, DOI: 10.1089/cap.2021.0030.Peer-Reviewed Original ResearchConceptsPlacebo response ratesObsessive-compulsive disorderPlacebo responseDepression trialsResponse ratePlacebo improvementSymptom improvementAntidepressant trialsStratified subgroup analysisRandom-effects modelPediatric populationSubgroup analysisStudy visitNumber of subjectsPsychopharmacological trialsPubMed searchDifferent indicationsDiagnostic indicationsMean differenceAnxiety disordersTrialsDisordersPediatric anxietyPredictorsPossible correlates
2019
Meta-analysis of placebo group dropout in adult antidepressant trials
Li F, Nasir M, Olten B, Bloch MH. Meta-analysis of placebo group dropout in adult antidepressant trials. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2019, 98: 109777. PMID: 31697973, DOI: 10.1016/j.pnpbp.2019.109777.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPlacebo leadAntidepressant trialsDiagnostic indicationsPlacebo-controlled trialStratified subgroup analysisBaseline illness severityMore study visitsDropout rateOverall dropout rateFreeman-Tukey transformationLonger trial durationEarlier publication yearPlacebo groupIllness severitySubgroup analysisDepressive disorderStudy visitMeta-AnalysisTrial durationAnxiety disordersTrialsEfficiency of trialsSubject burdenDisordersMeta-Analysis of Placebo Response in Adult Antidepressant Trials
Li F, Nasir M, Olten B, Bloch MH. Meta-Analysis of Placebo Response in Adult Antidepressant Trials. CNS Drugs 2019, 33: 971-980. PMID: 31573058, DOI: 10.1007/s40263-019-00662-y.Peer-Reviewed Original ResearchConceptsPlacebo response ratesPlacebo improvementSymptom improvementObsessive-compulsive disorderResponse rateDiagnostic indicationsAntidepressant trialsRandomized placebo-controlled trialPlacebo-controlled trialStratified subgroup analysisSecond-generation antidepressantsPlacebo comparison groupFuture antidepressantsSubgroup analysisClinical trialsPlacebo responseTrial characteristicsGreater magnitudeDepression trialsMeta-AnalysisUS sitesTrial durationAntidepressantsLanguage limitsMean difference
2017
Meta-analysis: Risk of dry mouth with second generation antidepressants
Cappetta K, Beyer C, Johnson JA, Bloch MH. Meta-analysis: Risk of dry mouth with second generation antidepressants. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 84: 282-293. PMID: 29274375, DOI: 10.1016/j.pnpbp.2017.12.012.Peer-Reviewed Original ResearchConceptsDry mouthSecond-generation antidepressantsGreater riskAntidepressant agentsGeneration antidepressantsPlacebo-controlled trialPooled risk ratioStratified subgroup analysisReceptor affinity profileSNRI classMedication classesAntidepressant medicationAtypical antidepressantsRisk ratioSubgroup analysisDepressive disorderSTUDY SELECTIONPubMed searchDATA SOURCESSNRIsDiagnostic indicationsSSRIsAntidepressantsAnxiety diagnosesAnxiety disordersEfficacy of antipsychotics for irritability and aggression in children: a meta-analysis
van Schalkwyk GI, Lewis AS, Beyer C, Johnson J, van Rensburg S, Bloch MH. Efficacy of antipsychotics for irritability and aggression in children: a meta-analysis. Expert Review Of Neurotherapeutics 2017, 17: 1045-1053. PMID: 28847182, DOI: 10.1080/14737175.2017.1371012.Peer-Reviewed Original ResearchConceptsDegree of sedationSubgroup analysisDiagnostic indicationsOverall dose effectEfficacy of risperidoneStratified subgroup analysisEfficacy of antipsychoticsIndividual antipsychotic agentsChoice of agentRange of diagnosesSpecific medicationsAntipsychotic efficacyAntipsychotic agentsAntipsychotic doseClinical dataOverall effect sizeAntipsychoticsNegative psychosocial outcomesIrritabilityPsychosocial outcomesEfficacyDiagnosisDose effectSedationRisperidone