The current state-of-the-art in pharmacotherapy for pediatric generalized anxiety disorder
Castagna P, Farahdel E, Potenza M, Crowley M. The current state-of-the-art in pharmacotherapy for pediatric generalized anxiety disorder. Expert Opinion On Pharmacotherapy 2023, 24: 835-847. PMID: 37074259, PMCID: PMC10197951, DOI: 10.1080/14656566.2023.2199921.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSelective serotonin reuptake inhibitorsSelective norepinephrine reuptake inhibitorGeneralized anxiety disorderAnxiety disordersReuptake inhibitorsPediatric generalized anxiety disorderBetter long-term outcomesSecond-line treatmentNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsFirst-line interventionLong-term outcomesCombination of psychotherapyPrevalent psychiatric disordersEvidence-based statePediatric anxiety disordersArt pharmacotherapyModerate effect sizeFunctional outcomeEarly recognitionMood disordersElevated riskPsychiatric disordersBetter outcomesElectronic databasesUse of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation
Beckenstrom A, Coloma P, Dawson G, Finlayson A, Malik A, Post A, Steiner M, Potenza M. Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation. Neuroscience & Biobehavioral Reviews 2023, 147: 105107. PMID: 36828161, PMCID: PMC10165155, DOI: 10.1016/j.neubiorev.2023.105107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExperimental medicine approachPerformance outcome measuresPsychiatric disordersMedicine approachReal-world clinical practiceOrexin neuropeptide systemMarkers of efficacyPatient advocacy groupsOrexin modulationReceptor modulationSymptom evaluationReceptor modulatorsClinical studiesMood disordersPreclinical studiesNeuropeptide systemsPsychiatric treatmentAnimal modelsPathological mechanismsClinical practiceClinical researchClinical useBrain functionTranslational researchPotential target