Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications
Etxandi M, Baenas I, Mora-Maltas B, Granero R, Fernández-Aranda F, Tovar S, Solé-Morata N, Lucas I, Casado S, Gómez-Peña M, Moragas L, del Pino-Gutiérrez A, Tapia J, Valenciano-Mendoza E, Potenza M, Gearhardt A, Diéguez C, Jiménez-Murcia S. Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications. Journal Of Behavioral Addictions 2023, 12: 1019-1031. PMID: 38141066, PMCID: PMC10786224, DOI: 10.1556/2006.2023.00051.Peer-Reviewed Original ResearchConceptsBody mass indexLeptin concentrationsFood addictionPlasma concentrationsHigher body mass indexAppetite-regulating hormonesYale Food Addiction Scale 2.0Gambling disorderSemi-structured clinical interviewLiver-expressed antimicrobial peptide 2Clinical featuresMass indexAppetite regulationHormonal variablesBlood samplesLifetime diagnosisPatientsAntimicrobial peptide 2Clinical InterviewNeuropsychological featuresPoor inhibitory controlAnthropometric variablesEndocrine measuresHormonal concentrationsLeptinRelationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age