2022
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity
Iturria-Medina Y, Adewale Q, Khan A, Ducharme S, Rosa-Neto P, O'Donnell K, Petyuk V, Gauthier S, De Jager P, Breitner J, Bennett D. Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity. Science Advances 2022, 8: eabo6764. PMID: 36399579, PMCID: PMC9674284, DOI: 10.1126/sciadv.abo6764.Peer-Reviewed Original ResearchConceptsMolecular taxonomy of ADAlzheimer's diseaseMolecular dataAlzheimer's disease progressionGenetic variationDNA methylationPattern of alterationsAD dementia progressionAD variantsCell typesPostmortem brainsHeterogeneous disorderBiological domainSpatial pattern of alterationAlzheimerClinical heterogeneityTaxonomyAD subtypesMetabolomic profilesSpatial patternsMolecular indicesAdvanced machine learning analysisDisease progressionRNADNA
2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnxietyChildDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansMalePregnancyConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhoodInternalizing symptoms associate with the pace of epigenetic aging in childhood
Tollenaar MS, Beijers R, Garg E, Nguyen TTT, Lin DTS, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ, O'Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood. Biological Psychology 2021, 159: 108021. PMID: 33460784, DOI: 10.1016/j.biopsycho.2021.108021.Peer-Reviewed Original ResearchMeSH KeywordsAgingChildChild, PreschoolDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansLongitudinal StudiesConceptsAdvanced biological agingChildhood psychiatric symptomsAge 6Longitudinal cohort studyInternalizing symptomsBiological agingChild mental healthCohort studyBuccal epithelial cellsPsychiatric symptomsSymptomsMental healthEpithelial cellsInternalizing disordersStatistical significanceAge 2.5Highest EAAExternalizing symptomsChildhoodEpigenetic agingHorvath clockGenome-wide DNA methylationEAA
2019
Biological embedding of experience: A primer on epigenetics
Aristizabal MJ, Anreiter I, Halldorsdottir T, Odgers CL, McDade TW, Goldenberg A, Mostafavi S, Kobor MS, Binder EB, Sokolowski MB, O'Donnell KJ. Biological embedding of experience: A primer on epigenetics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 117: 23261-23269. PMID: 31624126, PMCID: PMC7519272, DOI: 10.1073/pnas.1820838116.BooksConceptsEpigenetic mechanismsSpecific epigenetic mechanismsEpigenetic landscapeEpigenome editingDNA sequencesBiological embeddingGene expressionBiological processesCell typesComparative animalHuman longitudinal studiesMolecular profilingPotential roleCorrelative dataEpigenomeGenomeRecent advancesEpigeneticsEditingProfilingCausal dataPrimersMechanismSequenceExpressionThe PedBE clock accurately estimates DNA methylation age in pediatric buccal cells
McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 117: 23329-23335. PMID: 31611402, PMCID: PMC7519312, DOI: 10.1073/pnas.1820843116.Peer-Reviewed Original Research