2020
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment
Barth B, Bizarro L, Miguel PM, Dubé L, Levitan R, O'Donnell K, Meaney MJ, Silveira PP. Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment. Appetite 2020, 148: 104594. PMID: 31927071, DOI: 10.1016/j.appet.2020.104594.Peer-Reviewed Original ResearchMeSH KeywordsAdultChild BehaviorChild DevelopmentChild, PreschoolCohort StudiesEatingEmotionsFamily ConflictFeeding BehaviorFemaleGene ExpressionGenetic Predisposition to DiseaseHumansHyperphagiaInfantInfant, NewbornMachine LearningMaleMother-Child RelationsMothersObesityReceptors, Dopamine D4SingaporeSocial EnvironmentConceptsPositive environmentEmotional eatingEating Behavior QuestionnaireChildren's Eating Behaviour QuestionnaireGenetic differential susceptibilityDopamine D4 receptor geneD4 receptor geneBehavior QuestionnaireMonths of agePositive outcomesDRD4 genePositive settingEatingDifferential susceptibilityMAVANFurther evidenceOutcome measuresDRD4Susceptibility stateAdverse environmentsIndividualsQuestionnaireMeasuresDesireEvidence
2017
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.Peer-Reviewed Original ResearchConceptsEarly life adversityNeurodevelopmental outcomesPrenatal adversityChild Behavior ChecklistGenetic scoreAdversity scoreLife adversityCommunity birth cohortYears of agePervasive developmental problemsMaternal smokingGestational ageBirth weightLater riskPrenatal exposureAdverse exposuresBehavioral alterationsBirth cohortSerotonin transporter geneFetal periodPostnatal influencesPrefrontal cortexRelevant single nucleotide polymorphismsSerotonin transporterPrenatal life
2016
Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3
Janssen AB, Capron LE, O'Donnell K, Tunster SJ, Ramchandani PG, Heazell AE, Glover V, John RM. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 2016, 46: 2999-3011. PMID: 27523184, PMCID: PMC5080674, DOI: 10.1017/s0033291716001598.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionFetal growth restrictionPrenatal depressionPlacental expressionGrowth restrictionMedical notesDepression scoresFurther independent cohortImpaired placental functionPlacental lactogen productionAdverse neurodevelopmental outcomesDiagnosis of depressionMaternal depression scoresPoor offspring outcomesMaternal prenatal stressCyclin-dependent kinase inhibitor 1CPlacental gene expressionHigher depression scoresAberrant placental expressionNeurodevelopmental outcomesCohort participantsFetal growthPleckstrin homology-like domain familyPlacental functionMaternal depression