2023
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptomsThe impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study.
Henry M, Chen L, Meaney M, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Deamond H, Lang J, Silver J, Ducharme L, Mascarella M, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. The impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study. Journal Of Clinical Oncology 2023, 41: 6063-6063. DOI: 10.1200/jco.2023.41.16_suppl.6063.Peer-Reviewed Original ResearchNeck cancerPolygenic risk scoresGenetic predispositionRisk scoreSuicidal ideationConsecutive adult patientsMedical chart reviewTreatment of patientsLongitudinal studyProspective longitudinal studyQuality of lifePost-treatment periodAdult patientsChart reviewPrimary HNCPrevious historyMedical variablesPatientsSaliva samplesLife compromiseCancerPast historyPsychosocial vulnerabilityMaternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic riskGenetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
Henry M, Harvey R, Chen L, Meaney M, Nguyen T, Kao H, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Greenwood C, Melnychuk D, Gold P, Chartier G, Black M, Mascarella M, MacDonald C, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study. Journal Of Affective Disorders 2023, 331: 149-157. PMID: 36948466, DOI: 10.1016/j.jad.2023.03.007.Peer-Reviewed Original ResearchConceptsSymptom burdenNeck cancerGenetic predispositionPolygenic risk scoresRisk scoreAnxiety disordersImmediate post-treatment periodMedical chart reviewDose of radiotherapyStructured Clinical InterviewHigher polygenic risk scoreLongitudinal studyProspective longitudinal studyLife-threatening diseaseDose-related responsePost-treatment periodChart reviewHADS anxietyCancer survivalHigh prevalencePrimary headHigh riskDSM disordersPatientsClinical Interview
2022
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development
Perret LC, Boivin M, Morneau‐Vaillancourt G, Andlauer TFM, Paquin S, Langevin S, Girard A, Turecki G, O'Donnell K, Tremblay RE, Côté SM, Gouin J, Ouellet‐Morin I, Geoffroy M. Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development. Journal Of Child Psychology And Psychiatry 2022, 64: 388-396. PMID: 36124742, DOI: 10.1111/jcpp.13706.Peer-Reviewed Original ResearchConceptsDepressive symptomsGenetic predispositionQuebec Longitudinal StudyPolygenic risk scoresRisk scoreSelf-reported depressive symptomsLongitudinal studyIndividual genetic predispositionSuch gene-environment interactionsGene-environment interactionsSuch symptomsSymptomsDepressionChild developmentPredispositionAdolescencePeer victimisationFuture studiesEarly adolescenceScoresRiskAdolescentsAssociation
2021
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis
2020
Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder
Chen LM, Tollenaar MS, Dass S, Bouvette-Turcot AA, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen LM, MacIsaac JL, Kobor MS, Beijers R, de Weerth C, Silveira PP, Karama S, Meaney MJ, O'Donnell KJ. Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder. Development And Psychopathology 2020, 32: 1810-1821. PMID: 33427178, DOI: 10.1017/s0954579420001418.Peer-Reviewed Original ResearchConceptsMaternal antenatal depressionAttention-deficit/hyperactivity disorderAntenatal depressionChild mental healthPolygenic risk scoresMental healthHyperactivity disorderChild mental health symptomsMental health symptomsConsiderable inter-individual variationConventional polygenic risk scoresMaternal depressionRisk scoreHealth symptomsReplication cohortSynaptic functionGenomic riskChild genetic variationInter-individual variationNeuronal developmentSimilar findingsDepressionSingle nucleotide polymorphismsDevelopmental originsBehavioral problems
2019
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children
Miguel PM, Pereira LO, Barth B, de Mendonça Filho EJ, Pokhvisneva I, Nguyen TTT, Garg E, Razzolini BR, Koh DXP, Gallant H, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP. Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children. Biological Psychiatry 2019, 86: 621-630. PMID: 31142432, DOI: 10.1016/j.biopsych.2019.03.983.Peer-Reviewed Original ResearchConceptsExpression-based polygenic risk scoreGray matter densityBrain gray matter densityPrefrontal cortexHypoxic-ischemic conditionsHistory of exposurePrefrontal cortex expressionExecutive functionIdentification of childrenHypoxia-ischemiaPerinatal complicationsHealthy childrenRisk factorsPolygenic risk scoresHigh riskRisk scoreDopamine reuptakeBirth cohortCortex expressionPoor oxygenationImpaired executive functionBrain developmentGenetic polymorphisms
2017
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
Qiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O'Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ, . Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. Cerebral Cortex 2017, 27: 1-13. PMID: 28334351, PMCID: PMC6057508, DOI: 10.1093/cercor/bhx065.Peer-Reviewed Original ResearchMeSH KeywordsAsian PeopleBrainBrain MappingCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene Regulatory NetworksGenotypeGestational AgeHumansImage Processing, Computer-AssistedInfant, NewbornMagnetic Resonance ImagingMaleMaternal-Fetal RelationsPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsSocial ClassConceptsMaternal depressive symptomsDepressive symptomsHippocampal volumeRight amygdalaRight hippocampal volumeGlutamate receptor activityNeonatal brain developmentMajor depressive disorderRight amygdala volumeMother-infant dyadsFetal neurodevelopmentAmericas cohortAsian cohortDepressive disorderNeurotrophic signalingRight hippocampusCognitive-emotional functionRisk scoreAmygdala volumeSignificant interactionFetal developmentVentromedial prefrontal cortexSocio-economic statusBrain regionsReceptor activity