2024
Predictors of Participation in a Perinatal Text Message Screening Protocol for Maternal Depression and Anxiety: Prospective Cohort Study
Barnwell J, Robert C, Nguyen T, Davis K, Gratton C, Elgbeili G, Pham H, Meaney M, Montreuil T, O'Donnell K. Predictors of Participation in a Perinatal Text Message Screening Protocol for Maternal Depression and Anxiety: Prospective Cohort Study. JMIR Pediatrics And Parenting 2024, 7: e53786. PMID: 39361419, PMCID: PMC11487212, DOI: 10.2196/53786.Peer-Reviewed Original Research
2023
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptomsEarly intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scales
2022
The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort
Pagès N, Gorgui J, Wang C, Wang X, Zhao JP, Tchuente V, Lacasse A, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O'Donnell KJ, Eltonsy S, Chateau D, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V, Bérard A. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort. International Journal Of Environmental Research And Public Health 2022, 19: 12386. PMID: 36231687, PMCID: PMC9566261, DOI: 10.3390/ijerph191912386.Peer-Reviewed Original ResearchConceptsMaternal mental healthMental healthMean GAD-7 scorePregnant personsGAD-7 scoresNon-pandemic periodMental health assessmentCanada 2Public health policyLevel of depressionDepressive scoresMaternal depressionChinese cohortEDPS scoreCOVID-19 public health policiesCOVID-19 experienceHealth policyCohortSociodemographic variablesSelf-reported dataConception cohortsHealth assessmentCOVID-19COVID-19 pandemicScoresThe COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation
Bérard A, Gorgui J, Tchuente V, Lacasse A, Gomez YH, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O’Donnell K, Eltonsy S, Chateau D, Zhao JP, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V. The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation. International Journal Of Environmental Research And Public Health 2022, 19: 2926. PMID: 35270623, PMCID: PMC8910614, DOI: 10.3390/ijerph19052926.Peer-Reviewed Original ResearchConceptsMaternal mental healthTrimester of gestationMental healthMaternal depressionPregnancy statusMultivariate logistic regression modelDepressive symptom scoresPost-partum periodSevere maternal depressionCOVID-19 pandemicMental health measuresLogistic regression modelsAnxiety/stressPreterm birthSymptom scoresPregnant womenSevere depressionMaternal anxietyHealth measuresPregnant personsSignificant predictorsSociodemographic indicatorsTrimesterPregnancyCognitive problems
2020
Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder
Chen LM, Tollenaar MS, Dass S, Bouvette-Turcot AA, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen LM, MacIsaac JL, Kobor MS, Beijers R, de Weerth C, Silveira PP, Karama S, Meaney MJ, O'Donnell KJ. Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder. Development And Psychopathology 2020, 32: 1810-1821. PMID: 33427178, DOI: 10.1017/s0954579420001418.Peer-Reviewed Original ResearchConceptsMaternal antenatal depressionAttention-deficit/hyperactivity disorderAntenatal depressionChild mental healthPolygenic risk scoresMental healthHyperactivity disorderChild mental health symptomsMental health symptomsConsiderable inter-individual variationConventional polygenic risk scoresMaternal depressionRisk scoreHealth symptomsReplication cohortSynaptic functionGenomic riskChild genetic variationInter-individual variationNeuronal developmentSimilar findingsDepressionSingle nucleotide polymorphismsDevelopmental originsBehavioral problems
2016
Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3
Janssen AB, Capron LE, O'Donnell K, Tunster SJ, Ramchandani PG, Heazell AE, Glover V, John RM. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 2016, 46: 2999-3011. PMID: 27523184, PMCID: PMC5080674, DOI: 10.1017/s0033291716001598.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionFetal growth restrictionPrenatal depressionPlacental expressionGrowth restrictionMedical notesDepression scoresFurther independent cohortImpaired placental functionPlacental lactogen productionAdverse neurodevelopmental outcomesDiagnosis of depressionMaternal depression scoresPoor offspring outcomesMaternal prenatal stressCyclin-dependent kinase inhibitor 1CPlacental gene expressionHigher depression scoresAberrant placental expressionNeurodevelopmental outcomesCohort participantsFetal growthPleckstrin homology-like domain familyPlacental functionMaternal depression
2013
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression
Blakeley PM, Capron LE, Jensen AB, O'Donnell KJ, Glover V. Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression. Journal Of Psychosomatic Research 2013, 75: 341-345. PMID: 24119940, DOI: 10.1016/j.jpsychores.2013.07.002.Peer-Reviewed Original ResearchConceptsPlacental functionPrenatal symptomsA ExpressionSymptoms of depressionMaternal trait anxietyPlacental monoamine oxidaseElective caesareanNeurodevelopmental outcomesFetal exposureMAO AMaternal symptomsPregnant womenMaternal moodMonoamine oxidase APlacental expressionMaternal depressionFetal bloodSymptomsTrophoblast tissueMonoamine oxidaseSpecific polyclonal antibodiesDepressionOxidase APsychometric testsPlacentaPrenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort