2021
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis
2016
The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivity
Sokolowski HM, Vasquez OE, Unternaehrer E, Sokolowski DJ, Biergans SD, Atkinson L, Gonzalez A, Silveira PP, Levitan R, O’Donnell K, Steiner M, Kennedy J, Meaney MJ, Fleming AS, Sokolowski MB, teams O. The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivity. Cognitive Development 2016, 42: 62-73. PMID: 28827895, PMCID: PMC5562168, DOI: 10.1016/j.cogdev.2016.11.001.Peer-Reviewed Original ResearchGenetic variationCGMP-dependent protein kinaseAdult fruit fliesForaging (for) geneSocial insectsFruit flyProtein kinaseDrosophilaGene-environment interactionsGenesAllelesInsectsEarly environmentKinasePRKG1GeneticsFliesAdult individual differencesSelf-reported childhood adversityVariationC alleleMaternal adversityAssociatesEarly life adversityRs2043556Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
O'Donnell KJ, Meaney MJ. Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis. American Journal Of Psychiatry 2016, 174: 319-328. PMID: 27838934, DOI: 10.1176/appi.ajp.2016.16020138.BooksMeSH KeywordsAffectBirth WeightBrainChildChild, PreschoolChronic DiseaseFemaleFetal DevelopmentFetal Growth RetardationGene-Environment InteractionGlucocorticoidsHumansInfantInfant, NewbornMaleMaternal HealthMental DisordersNeurodevelopmental DisordersPregnancyPrenatal Exposure Delayed EffectsPsychopathologyRisk FactorsStress, PsychologicalTemperamentConceptsFetal growthMental healthFetal originLater psychopathologyMaternal mental healthDevelopmental originsNeurodevelopmental outcomesFetal neurodevelopmentChronic illnessObservational studyMaternal adversityMaternal anxietyStress mediatorsClinical relevanceFetal developmentPostnatal influencesAdult HealthDisease hypothesisFindings parallel studiesNeurodevelopmentGenetic factorsEmotional wellIllnessHealthRisk