2023
Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Apsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.Peer-Reviewed Original ResearchConceptsComplete blood countImmune cell proportionsAcute psychosocial stressCell proportionPsychosocial stressPsychosocial stress altersImmune cell subtypesAcute laboratory stressorEarly life adversityStress-exposed individualsChild maltreatmentPediatric cohortBlood countCell subtypesAcute stressStress-induced changesPathophysiological statesLife adversityCritical covariatesLaboratory stressorYoung adultsEffects of maltreatmentDNAm alterationsClinical populationsDNA methylation
2015
Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways
Shenk CE, Griffin AM, O'Donnell KJ. Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways. Development And Psychopathology 2015, 27: 1503-1514. PMID: 26535940, PMCID: PMC4774890, DOI: 10.1017/s0954579415000905.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD symptomsDepressive disorderRisk pathwaysChild maltreatmentPrevalent psychiatric conditionChild maltreatment populationSubstantiated child maltreatmentPsychiatric conditionsSymptomsClinical interventionsSaliva samplesLaboratory stressorDirect targetingFemale adolescentsCertain childrenChildrenEmotion regulationDisordersComparison conditionSignificant indirect effectCurrent studyMaltreatmentPathwayEmotion dysregulation