2022
Impulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different?
Gao T, Mei S, Li M, O'Donnell K, Caron J, Meng X. Impulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different? Personality And Individual Differences 2022, 184: 111208. DOI: 10.1016/j.paid.2021.111208.Peer-Reviewed Original ResearchQuality of lifeChildhood maltreatmentLarge community-based cohortSocial supportCommunity-based cohortCross-sectional studyEthical approvalInformed consentStudy sampleAdaptive coping strategiesHistory of maltreatmentCohortHigh impulsivityIntervention effortsEffect of impulsivityAssociationImpulsivityMaltreatmentMediation analysisCoping strategies
2019
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions
Dass S, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine 2019, 42: 188-202. PMID: 30922963, PMCID: PMC6491717, DOI: 10.1016/j.ebiom.2019.03.051.Peer-Reviewed Original ResearchMeSH KeywordsBrainEndophenotypesFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMalePhenotypePolymorphism, Single NucleotideReceptor, InsulinReproducibility of ResultsConceptsCognitive performancePolygenic scoresRelated mental disordersChild impulsivityIndividual differencesSpecific brain regionsInhibitory controlNeurobiological mechanismsCommunity sampleBrain regionsConventional GWASMesocorticolimbic systemImpulsivityMental disordersPsychopathologyAddictionNeural functionEndophenotypesAlzheimer's diseaseScoresADHDDisordersMemoryFunctioningGenetic score