2019
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O’Donnell K, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ, Räikkönen K, Binder E. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications 2019, 10: 2548. PMID: 31186427, PMCID: PMC6559955, DOI: 10.1038/s41467-019-10461-0.Peer-Reviewed Original ResearchConceptsDNA methylationEnvironmental factorsCellular functionsEpigenetic processesCord blood DNA methylationBlood DNA methylationMethylationGenetic variantsGenetic contributionIntegrated analysisPrenatal environmental factorsComplex disorderGenetic influencesGxE modelsGenotypesGWASRelative contributionGxEIndependent cohortCpGDisease riskEnrichmentVariants
2018
The early care environment and DNA methylome variation in childhood
Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ. The early care environment and DNA methylome variation in childhood. Development And Psychopathology 2018, 30: 891-903. PMID: 30068421, DOI: 10.1017/s0954579418000627.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylationDNA methylationGenetic variationGenetic dataEarly care environmentsMethylome variationInfant attachment styleInfant attachmentEpigenetic modificationsAttachment styleBuccal epithelial samplesMethylationMolecular signaturesPrenatal adversityGenetic contributionInfant developmentChild genetic variationInfant cognitive developmentDisorganized attachment styleLater mental health problemsNegative effectsEarly intervention programsChild mental healthMental health problemsCognitive development