2023
A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental health
2018
Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment
Bouvette-Turcot A, Meaney M, O’Donnell K. Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment. Child Maltreatment Solutions Network 2018, 89-119. DOI: 10.1007/978-3-319-72589-5_7.Peer-Reviewed Original ResearchMental healthEarly adversityEarly life adversityLater mental healthEarly childhood adversityLater riskClinical studiesPreclinical modelsCurrent evidenceMental disordersChildhood adversityLife adversityPutative mechanismsNeural developmentDNA methylationEarly social environmentChild maltreatmentEarly environmentHealthAdversityEpigenetic mechanisms
2015
Epigenetics and the developmental origins of vulnerability for mental disorders
Meaney M, O'Donnell K. Epigenetics and the developmental origins of vulnerability for mental disorders. 2015, 317-329. DOI: 10.1002/9781118381953.ch25.Chapters