2024
Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder
Wang R, Su Y, O'Donnell K, Caron J, Meaney M, Meng X, Li Y. Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder. Journal Of Affective Disorders 2024, 362: 688-697. PMID: 39029669, DOI: 10.1016/j.jad.2024.07.069.Peer-Reviewed Original ResearchMDD riskDepressive disorderPatterns of stressorsVulnerability-stress theoriesSusceptibility to MDDTranscriptome-wide association studyDimensions of stressorsLatent profile modelsLongitudinal community-based cohortPrefrontal cortexLifetime stressorsMDDGene expressionBrain amygdalaBasal gangliaStress researchNominal p-values <Southwest MontrealStressorsBrainFine-mapping analysisBrain cortexStudy cohortGenetic predispositionCortex
2021
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis