2022
To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort.
Li M, O'Donnell K, Caron J, Meaney M, Kobor M, D'Arcy C, Su Y, Liu A, Meng X. To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort. Development And Psychopathology 2022, 36: 50-61. PMID: 36102218, DOI: 10.1017/s0954579422000918.Peer-Reviewed Original ResearchMajor depressive disorderLongitudinal community-based cohortCommunity-based cohortDepressive disorderChildhood maltreatmentRisk of MDDSocial supportSubsequent major depressive disorderGenetic predispositionDirect effectPrevention programsSociodemographic characteristicsNegative copingNegative coping strategiesCoping strategiesPositive coping strategiesCohortDisordersPotential factorsPositive copingMediation analysisRobust evidenceDetrimental effectsCopingMaltreatmentIntegrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
Meng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderRisk of MDDDepressive disorderMDD subtypesMDD diagnosisRisk categorizationMajor public health problemLongitudinal community-based cohortCommunity-based cohortRisk prediction toolsGenetic variantsPublic health problemPrevalent mental disordersRisk prediction modelMDD cohortMDD patientsGenetic predispositionHealth problemsEarly identificationMental disordersMDD casesPotential genetic variantsDisordersCohortSubtypesImpulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different?
Gao T, Mei S, Li M, O'Donnell K, Caron J, Meng X. Impulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different? Personality And Individual Differences 2022, 184: 111208. DOI: 10.1016/j.paid.2021.111208.Peer-Reviewed Original ResearchQuality of lifeChildhood maltreatmentLarge community-based cohortSocial supportCommunity-based cohortCross-sectional studyEthical approvalInformed consentStudy sampleAdaptive coping strategiesHistory of maltreatmentCohortHigh impulsivityIntervention effortsEffect of impulsivityAssociationImpulsivityMaltreatmentMediation analysisCoping strategies
2021
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis