2023
Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylation
2022
Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample
Beijers R, Thije I, Bolhuis E, O'Donnell K, Tollenaar M, Shalev I, Hastings W, MacIsaac J, Lin D, Meaney M, Kobor M, Belsky J, de Weerth C. Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample. Psychophysiology 2022, 60: e14205. PMID: 36323627, DOI: 10.1111/psyp.14205.Peer-Reviewed Original ResearchConceptsChildhood risk exposuresLow-risk community sampleAge 6Cortisol reactivityAge 10Cumulative risk exposureCommunity sampleCellular agingPhysical health outcomesHealth outcomesStressor exposureTelomere lengthSecondary findingsLater lifeChild cortisol reactivityRegression analysisSignificant main effectFurther investigationExposurePositive correlationMore researchStrong conclusionsAgingBiomarkers
2019
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions
Dass S, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine 2019, 42: 188-202. PMID: 30922963, PMCID: PMC6491717, DOI: 10.1016/j.ebiom.2019.03.051.Peer-Reviewed Original ResearchMeSH KeywordsBrainEndophenotypesFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMalePhenotypePolymorphism, Single NucleotideReceptor, InsulinReproducibility of ResultsConceptsCognitive performancePolygenic scoresRelated mental disordersChild impulsivityIndividual differencesSpecific brain regionsInhibitory controlNeurobiological mechanismsCommunity sampleBrain regionsConventional GWASMesocorticolimbic systemImpulsivityMental disordersPsychopathologyAddictionNeural functionEndophenotypesAlzheimer's diseaseScoresADHDDisordersMemoryFunctioningGenetic score
2014
The persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Development And Psychopathology 2014, 26: 393-403. PMID: 24621564, DOI: 10.1017/s0954579414000029.Peer-Reviewed Original ResearchConceptsPrenatal anxietyMaternal moodPostnatal maternal moodLongitudinal studyMaternal prenatal anxietyLarge community samplePrenatal maternal moodOccasions of measurementPsychiatric symptomsChild mental disordersChild psychiatric symptomsEmotional problemsCommunity sampleAvon Longitudinal StudyEmotional symptomsChildhood psychopathologyPostnatal moodAge 4MoodAnxietyPersisting effectProgramming hypothesisMental disordersPrenatal depressionMajor models
2013
Prenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort