2018
Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment
Bouvette-Turcot A, Meaney M, O’Donnell K. Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment. Child Maltreatment Solutions Network 2018, 89-119. DOI: 10.1007/978-3-319-72589-5_7.Peer-Reviewed Original ResearchMental healthEarly adversityEarly life adversityLater mental healthEarly childhood adversityLater riskClinical studiesPreclinical modelsCurrent evidenceMental disordersChildhood adversityLife adversityPutative mechanismsNeural developmentDNA methylationEarly social environmentChild maltreatmentEarly environmentHealthAdversityEpigenetic mechanismsDNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2015
Epigenetics and the developmental origins of vulnerability for mental disorders
Meaney M, O'Donnell K. Epigenetics and the developmental origins of vulnerability for mental disorders. 2015, 317-329. DOI: 10.1002/9781118381953.ch25.Chapters
2014
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues In Clinical Neuroscience 2014, 16: 321-333. PMID: 25364283, PMCID: PMC4214175, DOI: 10.31887/dcns.2014.16.3/canacker.Peer-Reviewed Original ResearchConceptsExpression of genesParent-offspring interactionsEpigenetic stateEpigenetic mechanismsEpigenetic programmingEpigenetic studiesStress responseGenesNonhuman speciesAdrenal functionExpressionSpeciesEarly life adversityEarly childhood adversityLater riskFuture studiesChildhood adversityLife adversityFunctionSocial adversityAlters