2019
What does immunology have to do with brain development and neuropsychiatric disorders?
Leckman J, Alvarenga P, Ravagnani B, Johnson I. What does immunology have to do with brain development and neuropsychiatric disorders? Revista De Medicina 2019, 98: 241-253. DOI: 10.11606/issn.1679-9836.v98i4p241-253.Peer-Reviewed Original ResearchImmune systemNormal brain developmentBrain developmentNeuropsychiatric disordersNeural circuitsGut-brain axisRelevant review articlesAutism spectrum disorderObsessive-compulsive disorderBody of evidenceImmune cellsMood disordersValid biomarkersSubset of individualsTourette syndromeNovel interventionsNeurodegenerative disordersPersonalized approachLiterature searchDisordersMultiple biological systemsPathobiologyNeural developmentTraditional literature searchIndividual microbiomes
2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model
2002
Development and natural history of mood disorders
Costello EJ, Pine DS, Hammen C, March JS, Plotsky PM, Weissman MM, Biederman J, Goldsmith HH, Kaufman J, Lewinsohn PM, Hellander M, Hoagwood K, Koretz DS, Nelson CA, Leckman JF. Development and natural history of mood disorders. Biological Psychiatry 2002, 52: 529-542. PMID: 12361667, DOI: 10.1016/s0006-3223(02)01372-0.Peer-Reviewed Original ResearchConceptsMood disordersMood disorders researchPediatric-onset bipolar disorderBipolar disorderUnipolar depressionNatural historySpecific risk factorsModel of pathogenesisPrecursor of depressionPsychotropic medicationsRisk infantsRisk factorsSuccessful treatmentHigh riskMultidisciplinary workgroupChildhood anxiety disordersJuvenile depressionDisorder researchEarly onsetProtective factorsAnxiety disordersPanel of expertsMental healthDisordersDepression