2022
Neuroimmunoendocrinology of Tourette Syndrome
Martino D, Johnson I, Escobar A, Leckman J. Neuroimmunoendocrinology of Tourette Syndrome. 2022, 257-276. DOI: 10.1093/med/9780197543214.003.0016.Peer-Reviewed Original ResearchTourette syndromeImmune-modulatory interventionsImmune competent cellsGeneration of ticsCortico-subcortical circuitsNormal brain developmentNeuroimmune interactionsKey molecular pathwaysGut dysbiosisAllergic illnessHigh riskImmune pathwaysPostnatal lifeTherapeutic interventionsImmune primingImmune systemRelated disordersNeural circuitsBrain developmentNeurodevelopmental disordersDisordersMolecular pathwaysSyndromeDate summaryMolecular mechanisms
2019
What does immunology have to do with brain development and neuropsychiatric disorders?
Leckman J, Alvarenga P, Ravagnani B, Johnson I. What does immunology have to do with brain development and neuropsychiatric disorders? Revista De Medicina 2019, 98: 241-253. DOI: 10.11606/issn.1679-9836.v98i4p241-253.Peer-Reviewed Original ResearchImmune systemNormal brain developmentBrain developmentNeuropsychiatric disordersNeural circuitsGut-brain axisRelevant review articlesAutism spectrum disorderObsessive-compulsive disorderBody of evidenceImmune cellsMood disordersValid biomarkersSubset of individualsTourette syndromeNovel interventionsNeurodegenerative disordersPersonalized approachLiterature searchDisordersMultiple biological systemsPathobiologyNeural developmentTraditional literature searchIndividual microbiomes
2017
Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders
Guloksuz SA, Abali O, Cetin E, Gazioglu S, Deniz G, Yildirim A, Kawikova I, Guloksuz S, Leckman JF. Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders. Brazilian Journal Of Psychiatry 2017, 39: 195-200. PMID: 28099628, PMCID: PMC7111377, DOI: 10.1590/1516-4446-2015-1843.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alphaNecrosis factor alphaS100B concentrationsPlasma concentrationsFactor alphaChildhood Autism Rating ScaleS100 calcium-binding protein BCalcium-binding protein BElevated plasma concentrationsTNF-α concentrationsAutism spectrum disorderIL-17AIL-10Cytokine concentrationsInflammatory cytokinesIL-6Peripheral concentrationsHealthy childrenIL-4Plasma levelsSpectrum disorderImmune functionInterferon gammaImmune systemS100B
2014
Commentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014)
Leckman JF. Commentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014). Journal Of Child Psychology And Psychiatry 2014, 55: 632-634. PMID: 24840172, DOI: 10.1111/jcpp.12259.Peer-Reviewed Original Research
2008
Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children
Leslie DL, Kozma L, Martin A, Landeros A, Katsovich L, King RA, Leckman JF. Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 1166-1172. PMID: 18724258, PMCID: PMC2783578, DOI: 10.1097/chi.0b013e3181825a3d.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesDepressive Disorder, MajorFemaleHealth SurveysHumansIncidenceInsurance, HealthMaleMigraine DisordersNeurocognitive DisordersObsessive-Compulsive DisorderOdds RatioOtitis MediaRiskSinusitisStreptococcal InfectionsTic DisordersTourette SyndromeUnited StatesConceptsMajor depressive disorderAttention-deficit/hyperactivity disorderPrior streptococcal infectionStreptococcal infectionObsessive-compulsive disorderTic disordersTourette syndromeNeuropsychiatric disordersConditional logistic regression modelsStreptococcal sore throatDiagnosis of OCDCase-control studyLogistic regression modelsSore throatIncident diagnosisEpidemiologic evidenceDepressive disorderSubsequent diagnosisNoninfectious conditionsScarlet feverChildren ages 4Immune systemInfectious diseasesInfectionDiagnosis