2020
Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling
Heiman GA, Rispoli J, Seymour C, Leckman JF, King RA, Fernandez TV. Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling. Frontiers In Neurology 2020, 11: 770. PMID: 32849224, PMCID: PMC7432137, DOI: 10.3389/fneur.2020.00770.Peer-Reviewed Original ResearchChronic tic disorderRecurrence risk estimatesTic disordersRecurrence riskTourette's disorderRisk estimatesNeuropsychiatric disordersPopulation-based family studyGenetic counselingFirst-degree relativesQuality of lifeFamily studiesVocal ticsPopulation prevalenceFamilial recurrence riskSuch counselingGenetic testingDisordersRiskCounselingEmpiric recurrence riskGenetic variantsRange of risksHeterogeneous genetic architectureComorbidities
2017
A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, Fernández de la Cruz L, Serlachius E, Leckman JF, Crowley JJ, Rück C, Almqvist C, Lichtenstein P, Larsson H. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Molecular Psychiatry 2017, 23: 1652-1658. PMID: 29133949, PMCID: PMC5951741, DOI: 10.1038/mp.2017.215.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAutoimmune diseasesChronic tic disorderIndividual autoimmune diseasesThird-degree relativesTic disordersRisk of ADsNational Patient RegisterPatterns of comorbidityFirst-degree relativesPatient RegisterPlacental transmissionNationwide studyBirth cohortCTD casesFamilial clusteringDisordersComorbiditiesPopulation controlsProbandsOCD probandsBiological relativesDiseaseFamilial linkRiskThe Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2012
Trajectory in obsessive-compulsive disorder comorbidities
de Mathis MA, Diniz JB, Hounie AG, Shavitt RG, Fossaluza V, Ferrão Y, Leckman JF, de Bragança Pereira C, do Rosario MC, Miguel EC. Trajectory in obsessive-compulsive disorder comorbidities. European Neuropsychopharmacology 2012, 23: 594-601. PMID: 22921470, DOI: 10.1016/j.euroneuro.2012.08.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHigher lifetime frequencyOCD patientsFirst diagnosisTic disordersSeparation anxiety disorderLifetime frequencyObsessive-compulsive disorder (OCD) comorbidityAnxiety disordersOnset of OCDDistribution of comorbiditiesSpecific comorbid diagnosesLifetime psychiatric diagnosesPost-traumatic stress disorderFirst comorbiditySymptom onsetClinical courseClinical presentationPsychiatric comorbidityDisorder comorbidityOCD courseBeck AnxietyComorbid disordersPsychiatric disordersComorbidities