Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nature Biotechnology 2009, 27: 361-368. PMID: 19329998, PMCID: PMC3566772, DOI: 10.1038/nbt.1533.Peer-Reviewed Original ResearchConceptsMethylation-sensitive restriction enzyme HpaIIRestriction enzyme HpaIIHuman genomeNext-generation sequencingMethylation signaturesHuman cellsEnzyme HpaIIPadlock probesGenomeMethylationHpaIISequencingUntargeted methodDNATargeted approachCells