2024
Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5
2018
Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders
Fan S, Lippard ETC, Sankar A, Wallace A, Johnston JAY, Wang F, Pittman B, Spencer L, Oquendo MA, Blumberg HP. Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders. Journal Of Affective Disorders 2018, 245: 1089-1097. PMID: 30699851, PMCID: PMC6903411, DOI: 10.1016/j.jad.2018.11.095.Peer-Reviewed Original ResearchConceptsMajor depressive disorderYoung adult suicide attemptersNon-suicide attemptersAdult suicide attemptersBipolar disorderSuicide attemptersFractional anisotropyDepressive disorderGM volumePrevention strategiesBrain circuitryYoung adultsBrain circuitry abnormalitiesAdolescents/young adultsWhite matter fractional anisotropyEarly prevention strategiesAdolescence/young adulthoodMagnetic resonance scanningWhite matter alterationsGray matter volumeSuicide prevention strategiesPrior suicide attemptsWM fractional anisotropyWhole-brain analysisWhite matter differences
2017
Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder
Weathers J, Lippard ETC, Spencer L, Pittman B, Wang F, Blumberg HP. Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 57: 111-117. PMID: 29413143, PMCID: PMC5806147, DOI: 10.1016/j.jaac.2017.11.014.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsDiffusion tensor imaging studyAdolescence/young adulthoodLongitudinal diffusion tensor imaging studyBipolar disorderVentral prefrontal cortexFractional anisotropyYoung adultsHealthy controlsWhite matterImaging studiesUncinate fasciculusYoung adulthoodUF fractional anisotropyWhole-brain analysisClinical factorsTime-related changesSignificant interactionLongitudinal neuroimagingPrefrontal cortexDTI scansNeurodevelopmental pathophysiologyAdultsAgeTrait features